merck millipore,默克密理愽
  • merck millipore,默克密理博,566324,SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem

  • merck millipore,默克密理博,566324,SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem

    产品名称：SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem
    产品型号：566324
    The SIRT2 Inhibitor, AGK2, also referenced under CAS 304896-28-4, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.

    merck millipore,默克密理博,566324,SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,566324,SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₃H₁₃Cl₂N₃O₂304896-28-4
    描述
    概述 A cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC50 = 3.5 µM) with little activity against SIRT1/3 (IC50 >50 µM). Prevents cellular α-tubulin deacetylation in HeLa cells in a dose-dependent manner and with little cytotoxic effect. Shown to rescue α-Synuclein-mediated toxicity both in primary rat embryo midbrain cultures in vitro and in a Drosophila PD model in vivo. The inactive isomer AGK7 (Cat. No. 566326) can be used as a negative control.
    产品目录编号 566324
    品牌系列 Calbiochem®
    同义词 Sirtuin 2 Inhibitor, 2-Cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-2-propenamide, SIRT2 Inhibitor I, SIRT1 Inhibitor IV
    参考
    参考 Outerio, T.F., et al. 2007. Science 317, 516.
    产品信息
    CAS号 304896-28-4
    形式 Yellow solid
    Hill配方 C₂₃H₁₃Cl₂N₃O₂
    化学配方 C₂₃H₁₃Cl₂N₃O₂
    Molar Mass 434.3
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,566324,SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem

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