merck millipore,默克密理愽
  • merck millipore,默克密理博,14-610,Flt-3 (D835Y) Protein, active, 10 µg

  • merck millipore,默克密理博,14-610,Flt-3 (D835Y) Protein, active, 10 µg

    产品名称：Flt-3 (D835Y) Protein, active, 10 µg
    产品型号：14-610
    Active, N-terminal GST tagged, recombinant human Flt3 amino acids 564-end, containing the mutation D835Y, for use in Kinase Assays.

    merck millipore,默克密理博,14-610,Flt-3 (D835Y) Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-610,Flt-3 (D835Y) Protein, active, 10 µg

    描述
    产品目录编号 14-610
    品牌系列 Upstate
    商名
    • Upstate
    描述 Flt-3 (D835Y) Protein, active, 10 µg
    概述 N-terminal GST tagged, recombinant human Flt3 amino acids 564-end, containing the mutation D835Y
    应用
    应用 Active, N-terminal GST tagged, recombinant human Flt3 amino acids 564-end, containing the mutation D835Y, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_004119.2
    Entrez基因汇总 This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
    基因符号
    • STK1
    • FLT3
    • STK-1
    • FLK2
    • CD135
    • OTTHUMP00000042340
    蛋白靶 Flt3
    纯化方法 Glutathione agarose affinity chromatography
    靶子系列 TK
    UniProt编号
    • P36888
    UniProt汇总 FUNCTION: SwissProt: P36888 # Receptor for the FL cytokine. Has a tyrosine-protein kinase activity.
    SIZE: 993 amino acids; 112903 Da
    SUBUNIT: Interacts with FIZ1 following ligand activation (By similarity).
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Bone marrow cells.
    SIMILARITY: SwissProt: P36888 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of 50μM Abltide (Catalog # 12-493)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-610,Flt-3 (D835Y) Protein, active, 10 µg

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