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品种反应性 主要应用 宿主 格式 抗体类型 Fg, R, M, H, B, Ch IHC, ICC M AlexaFluor®488 Monoclonal Antibody 描述 产品目录编号 MAB1567A4 描述 Anti-MAG Antibody, clone 513, Alexa Fluor® 488 Conjugate | MAB1567A4 Alternate Names - Siglec-4a
- Myelin-associated glycoprotein
背景信息 Myelin-associated glycoprotein (MAG), a member of the immunoglobulin superfamily, is a membrane glycoprotein of 100 kDa, and is thought to be involved in the process of myelination. Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG. MAG has been implicated in the inhibition of nerve regeneration in the CNS. 产品信息 格式 AlexaFluor®488 控制 - Adult mouse brain tissue
演示 Purified mouse monoclonal IgG1 conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 主要应用 - Immunohistochemistry
- Immunocytochemistry
应用说明 Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected MAG in rat E18 primary cortex cells. 生物信息 免疫原品种 L2 epitope carrying glycoprotein extract of 1-2 day old chicken brain 克隆 513 宿主 Mouse 同种型 IgG1 品种反应性 FrogRatMouseHumanBovineChicken Species Reactivity Note Demonstrated to react with Rat and Mouse. Predicted to react with Human, Bovine, Chicken, and Frog based on 100% sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002352
Entrez基因汇总 The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. 基因符号 - GMA
- MAG
纯化方法 Protein A purified UniProt编号 - P20916
UniProt汇总 FUNCTION: Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha2,3- linked sialic acid (By similarity).
SIZE: 626 amino acids; 69069 Da
SUBUNIT: Binds to RTN4R (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. & Contains 4 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.产品使用声明 质量保证 Evaluated by Immunohistochemistry in adult mouse brain tissue.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected MAG in adult mouse brain tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,14-733,c-Kit (V654A) Protein, active, 10 µg
下一件merck millipore产品：merck millipore,默克密理博,ABD38,Anti-SNAI1 (Snail homolog 1) Antibody
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