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merck millipore,默克密理博,ABD38,Anti-SNAI1 (Snail homolog 1) Antibody
产品名称：Anti-SNAI1 (Snail homolog 1) Antibody
产品型号：ABD38
Anti-SNAI1 (Snail homolog 1) Antibody is a Rabbit Polyclonal Antibody for detection of SNAI1 also known as Zinc finger protein SNAI1, Snail homolog 1 & has been validated in WB.
merck millipore,默克密理博,ABD38,Anti-SNAI1 (Snail homolog 1) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, M, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABD38 描述 Anti-SNAI1 (Snail homolog 1) Antibody Alternate Names - Protein sna
- Zinc finger protein SNAI1
- Protein snail homolog 1
背景信息 SNAI1, also known as Snail homolog 1, is a transcription factor that down regulates the expression of ectodermal genes within the mesoderm and is thought to be essential for mesoderm formation in the developing embryo. SNAI1 is expressed in the kidney and in mesenchymal and epithelial cell lines. Mutations in SNAI1 have been associated with tumors. 产品信息 格式 Affinity Purified 控制 - Rat brain tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-SNAI1 (Snail homolog 1) Antibody is a Rabbit Polyclonal Antibody for detection of SNAI1 also known as Zinc finger protein SNAI1, Snail homolog 1 & has been validated in WB. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: 1 µg/mL from a representative lot detected SNAI1 on 10 µg of mouse brain tissue lysate. 生物信息 免疫原品种 Linear peptide corresponding to human SNAI1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 HumanMouseRat Species Reactivity Note Demonstrated to react with Mouse and Rat. Predicted to react with Human based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005976
Entrez基因汇总 The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]. 基因符号 - SNAH
- SNAI1
纯化方法 Affinity purified UniProt编号 - O95863
UniProt汇总 FUNCTION: Involved in the epithelial to mesenchymal transition (EMT) and formation and maintenance of embryonic mesoderm (By similarity). Binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription.
SUBUNIT STRUCTURE: Interacts with FBXL14 and GSK3B. Interacts with BTRC; interaction occurs when it is phosphorylated on the destruction motif.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.
TISSUE SPECIFICITY: Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.
PTM: Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination.
Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation.
SEQUENCE SIMILARITIES: Belongs to the snail C2H2-type zinc-finger protein family.
Contains 4 C2H2-type zinc fingers.产品使用声明 质量保证 Evaluated by Western Blot in rat brain tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected SNAI1 on 10 µg of rat brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,AB7821,Anti-Collagen Type VI Antibody
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