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  • merck millipore,默克密理博,AB7821,Anti-Collagen Type VI Antibody

  • merck millipore,默克密理博,AB7821,Anti-Collagen Type VI Antibody

    产品名称：Anti-Collagen Type VI Antibody
    产品型号：AB7821
    Anti-Collagen Type VI Antibody is an antibody against Collagen Type VI for use in ELISA, IH.

    merck millipore,默克密理博,AB7821,Anti-Collagen Type VI Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB7821,Anti-Collagen Type VI Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, ELISARbSerumPolyclonal Antibody
    描述
    产品目录编号 AB7821
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Collagen Type VI Antibody
    产品信息
    格式 Serum
    演示 Pooled antisera was cross-absorbed against immobilized human serum proteins and collagen types IV and V. The IgG fraction was then precipitated with ammonium sulfate and subsequently dialyzed. Lyophilized from 500μL of 10mM Na-phosphate, 150mM NaCl, pH 7.5 with 0.1% mannitol.
    应用
    应用 Anti-Collagen Type VI Antibody is an antibody against Collagen Type VI for use in ELISA, IH.
    主要应用
    • Immunohistochemistry
    • ELISA
    应用说明 Immunohistochemistry: 1:10-1:40 dilution of reconstitute for indirect immunofluorescent staining of frozen tissue sections.

    ELISA: 1:10,000 dilution of reconstitute for ELISA on human collagen type VI.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Human placental collagen type VI
    宿主 Rabbit
    特异性 Human collagen type I <0.5%

    Human collagen type II <0.5%

    Human collagen type III <0.5%

    Human collagen type IV <0.5%

    Human collagen type V 5%

    Human collagen type VI 100 %

    Human fibronectin <0.5%

    Human albumin <0.5%

    Human immunoglobulin <0.5%
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001848.2
    Entrez基因汇总 The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.
    基因符号
    • OPLL
    • COL6A1
    UniProt编号
    • P12109
    UniProt汇总 FUNCTION: SwissProt: P12109 # Collagen VI acts as a cell-binding protein.
    SIZE: 1028 amino acids; 108529 Da
    SUBUNIT: Trimers composed of three different chains: alpha 1(VI), alpha 2(VI), and alpha 3(VI).
    SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
    PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
    DISEASE: SwissProt: P12109 # Defects in COL6A1 are a cause of Bethlem myopathy (BM) [MIM:158810]. BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles.
    SIMILARITY: SwissProt: P12109 ## Contains 3 VWFA domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain lyophilized at -20°C for up to 12 months. Reconstitute with 500uL of distilled water or saline. Store reconstitute between 2 and 8°C for up to two months. Remove any insoluble material by microcentrifugation before use.
    包装信息
    数量 500 µg

    merck millipore,默克密理博,AB7821,Anti-Collagen Type VI Antibody

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