merck millipore,默克密理愽
  • merck millipore,默克密理博,14-733,c-Kit (V654A) Protein, active, 10 µg

  • merck millipore,默克密理博,14-733,c-Kit (V654A) Protein, active, 10 µg

    产品名称：c-Kit (V654A) Protein, active, 10 µg
    产品型号：14-733
    V654A is an acquired resistance mutation found in patients with gastrointestinal stromal tumours (GISTs) undergoing treatment with Imatinib. The V654A mutation is strongly correlated with imatinib res More>>

    merck millipore,默克密理博,14-733,c-Kit (V654A) Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-733,c-Kit (V654A) Protein, active, 10 µg

    描述
    产品目录编号 14-733
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 c-Kit (V654A) Protein, active, 10 µg
    概述 N-terminal GST tagged, recombinant human cKit, amino acids 544 - end containing the V654A mutation. Co-ordinates encompass the cytoplasmic domain (544-976) according in Swiss Prot P10721. V654A is an acquired resistance mutation which has been found in patients with gastrointestinal stromal tumours (GISTs) undergoing treatment with Imatinib. The V654A mutation is strongly correlated with imatinib resistance and rapid progession of GISTs. (Chen LL et al., Cancer Research, (2004); 64:5913-5919).
    应用
    应用 V654A is an acquired resistance mutation found in patients with gastrointestinal stromal tumours (GISTs) undergoing treatment with Imatinib. The V654A mutation is strongly correlated with imatinib resistance & rapid progession of GISTs.
    主要应用
    • Kinase Assay
    生物信息
    来源 recombinant protein expressed in Sf21 cells
    品种 Human
    特异活性 169 U/mg, where one unit of cKit (V654A) activity is defined as 1nmol phosphate incorporated into 250 μM GGMEDIYFEFMGGKKK per minute at 30 °C with a final ATP concentration of 100 μM.
    Entrez基因编号
    • NM_001093772.1
    • NM_000222.2
    Entrez基因汇总 This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • c-kit
    • KIT
    • C-Kit
    • PBT
    • CD117
    • SCFR
    蛋白靶 c-Kit
    纯化方法 Purified using glutathione-agarose. Purity 99% by SDS-PAGE and Coomassie blue staining.
    靶子系列 TK
    UniProt编号
    • P10721
    UniProt汇总 FUNCTION: SwissProt: P10721 # This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).
    SIZE: 976 amino acids; 109865 Da
    SUBUNIT: Interacts with APS. Interacts with the tenth PDZ domain of MPDZ.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DISEASE: SwissProt: P10721 # Defects in KIT are a cause of piebaldism [MIM:172800]. Piebaldism is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. & Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [MIM:606764]. & Defects in KIT have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).
    SIMILARITY: SwissProt: P10721 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of 250 μM GGMEDIYFEFMGGKKK.
    Purity was assessed by SDS-PAGE and Coomassie blue staining using 3 μg of active cKit (V654A).
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 6 months at -70 °C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
    Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70 °C.
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-733,c-Kit (V654A) Protein, active, 10 µg

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