merck millipore,默克密理博,260010,Demethylasterriquinone B1 - CAS 78860-34-1

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merck millipore,默克密理博,260010,Demethylasterriquinone B1 - CAS 78860-34-1 - Calbiochem
产品名称：Demethylasterriquinone B1 - CAS 78860-34-1 - Calbiochem
产品型号：260010
A cell-permeable unsymmetrical bis-indolylquinone insulin mimic with anti-diabetic activity in animal models.

merck millipore,默克密理博,260010,Demethylasterriquinone B1 - CAS 78860-34-1 - Calbiochem

产品介绍

merck millipore,默克密理博,260010,Demethylasterriquinone B1 - CAS 78860-34-1 - Calbiochem

重要规格表

经验配方	CAS号
C₃₂H₃₀N₂O₄	78860-34-1

描述
概述	A cell-permeable unsymmetrical bis-indolylquinone insulin mimic with anti-diabetic activity in animal models. Selectively stimulates insulin receptor (IR) tyrosine kinase activity (EC₅₀ ~ 6 µM in CHO•IR cells), while showing little effect towards IGF-1R, EGFR, or PDGFR. Also acts as an agonist for the neurotrophin receptors TrkA, B, and C in both cortical neurons and dorsal root ganglion neurons (~ 20 µM). DMAQ-B1 and insulin show differential effects on cellular gene expression profiles and DMAQ-B1 is a more selective agonist than insulin for the IR-mediated activation of PI-3 kinase/Akt pathway.
产品目录编号	260010
品牌系列	Calbiochem®
同义词	2-[2-(1,1-Dimethylallyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methylbut-2-enyl)-1H-indol-3-yl][1,4]benzoquinone, 2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-6-[2-(1,1-dimethyl-allyl)-1H-indol-3-yl]-[1,4]benzoquinone, L-783,281, DMAQ-B1, DAQ B1

参考
参考	Webster, N.J., et al. 2003. Chembiochem 4, 379. Pirrung, M.C., et al. 2002. J. Org. Chem. 6, 23. Westerlund, J., et al. 2002. Diabetes 51, S50. Roper, M.G., et al. 2002. Diabetes 51, S43. Air, E.L., et al. 2002. Nat. Med. 8, 179. Wilkie, N., et al. 2001. J. Neurochem. 78, 1135. Salituro, G.M., et al. 2001. Recent Prog. Horm. Res. 56, 107. Liu, K., et al. 2000. J. Med. Chem. 43, 3487. Zhang, B., et al. 1999. Science 284, 974.

参考

Webster, N.J., et al. 2003. Chembiochem 4, 379.
Pirrung, M.C., et al. 2002. J. Org. Chem. 6, 23.
Westerlund, J., et al. 2002. Diabetes 51, S50.
Roper, M.G., et al. 2002. Diabetes 51, S43.
Air, E.L., et al. 2002. Nat. Med. 8, 179.
Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
Salituro, G.M., et al. 2001. Recent Prog. Horm. Res. 56, 107.
Liu, K., et al. 2000. J. Med. Chem. 43, 3487.
Zhang, B., et al. 1999. Science 284, 974.

产品信息
CAS号	78860-34-1
具有ATP竞争性	N
形式	Bluish black solid
Hill配方	C₃₂H₃₀N₂O₄
化学配方	C₃₂H₃₀N₂O₄
Molar Mass	506.6
可逆	N
结构配方图像

生物信息
主靶	Insulin receptor (IR) tyrosine kinase activity
主靶IC₅₀	EC50 ~ 6 µM stimulating insulin receptor (IR) tyrosine kinase activity in CHO•IR cells
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Shipped with Blue Ice or with Dry Ice
毒性	Irritant
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.