merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE126,Anti-SR protein family Antibody, clone 16H3

  • merck millipore,默克密理博,MABE126,Anti-SR protein family Antibody, clone 16H3

    产品名称：Anti-SR protein family Antibody, clone 16H3
    产品型号：MABE126
    Anti-SR protein family Antibody, clone 16H3 is a Mouse Monoclonal Antibody for detection of SR protein family also known as arginine/serine-rich splicing factor 6 & has been validated in WB, IP, ICC.

    merck millipore,默克密理博,MABE126,Anti-SR protein family Antibody, clone 16H3

  • 产品介绍
  • merck millipore,默克密理博,MABE126,Anti-SR protein family Antibody, clone 16H3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE126
    描述 Anti-SR protein family Antibody, clone 16H3
    Alternate Names
    • pre-mRNA splicing factor SRP55
    • splicing factor, arginine/serine-rich 6
    • arginine/serine-rich splicing factor 6
    • splicing factor, arginine/serine-rich, 55 kDa
    • Pre-mRNA-splicing factor SRP55
    背景信息 Ser-Arg-rich (SR) proteins make up a family of functionally and structurally conserved phosphoproteins, and are required components of alternative and constitutive pre-mRNA splicing. SR proteins are characterized by their modular composition consisting of two domains of interest: an N-terminal RNA recognition motif (RRM) which serves in the determination of DNA-binding specificity, and the RS domain, an arginine and serine rich, C-terminal domain that serves as a shuttling and localization director of SR proteins and as a splicing activation domain. They are involved in various aspects of pre-mRNA splicing and in spliceosome assembly including the identification and appropriation of splice-sites and the manipulation of alternative splicing regulation.
    产品信息
    格式 Purified
    控制
    • HeLa nuclear extract
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-SR protein family Antibody, clone 16H3 is a Mouse Monoclonal Antibody for detection of SR protein family also known as arginine/serine-rich splicing factor 6 & has been validated in WB, IP, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP (Neugebauer, KM, et al. (1995).

    Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in IC. (Neugebauer, KM, et al. (1995).
    生物信息
    免疫原品种 Dephosphorylated bovine SRp55 and GST-tagged recombinant dephosphorylated SRp55 (Neugebauer, KM et. al 1995).
    克隆 16H3
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 This antibody recognizes the four nuclear proteins SRp75, SRp55, SRp40, and SRp20, plus ~20 other prominent nuclear proteins believed to correspond to the SR family.
    同种型 IgG1κ
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with human.
    Predicted to react with mouse and rat based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_006266
    Entrez基因汇总 The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants.
    基因符号
    • SFRS6
    • SRP55
    • B52
    纯化方法 Protein G Purified
    UniProt编号
    • Q13247
    UniProt汇总 FUNCTION: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

    SUBUNIT STRUCTURE: Binds SFRS12.

    SUBCELLULAR LOCATION: Nucleus.

    PTM: Extensively phosphorylated on serine residues in the RS domain (By similarity).

    SEQUENCE SIMILARITIES: Belongs to the splicing factor SR family.

    Contains 2 RRM (RNA recognition motif) domains.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa nuclear extract.

    Western Blot Analysis: 0.5 µg/mL of this antibody detected SR proteins in 10 µg of HeLa nuclear extract.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE126,Anti-SR protein family Antibody, clone 16H3

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