merck millipore,默克密理愽
  • merck millipore,默克密理博,MAB5634,Anti-Spastin Antibody, clone Sp3G11/1

  • merck millipore,默克密理博,MAB5634,Anti-Spastin Antibody, clone Sp3G11/1

    产品名称：Anti-Spastin Antibody, clone Sp3G11/1
    产品型号：MAB5634
    Anti-Spastin Antibody, clone Sp3G11/1 detects level of Spastin & has been published & validated for use in WB, IH(P).

    merck millipore,默克密理博,MAB5634,Anti-Spastin Antibody, clone Sp3G11/1

  • 产品介绍
  • merck millipore,默克密理博,MAB5634,Anti-Spastin Antibody, clone Sp3G11/1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MAB5634
    描述 Anti-Spastin Antibody, clone Sp3G11/1
    Alternate Names
    • spastin)
    • spastic paraplegia 4 (autosomal dominant
    背景信息 Spastin is a distinct microtubule-severing protein. Autosomal dominant mutations in the SPG4 locus corresponding to spastin are the most common cause of hereditary spastic paraplegia (HSP), a neurodegenerative disease that afflicts the adult corticospinal tracts.
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3
    应用
    应用 Anti-Spastin Antibody, clone Sp3G11/1 detects level of Spastin & has been published & validated for use in WB, IH(P).
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry: Cat. # MAB5634 can detect Spastin in paraffin sections of human brain at 1:25 dilutions
    生物信息
    免疫原品种 Full length recombinant protein
    克隆 Sp3G11/1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Cat. # MAB5634 recognizes Spastin.
    同种型 IgG2aκ
    品种反应性 RatHumanMouse
    Species Reactivity Note Human, Mouse and Rat. Reactivity with other species has not been tested.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • Q9UBP0
    Entrez基因汇总 This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq]
    基因符号
    • spastin
    • ADPSP
    • FSP2
    • KIAA1083
    • OTTHUMP00000158570
    • SPG4
    纯化方法 Protein G purfied
    UniProt编号
    • Q9UBP0
    UniProt汇总 FUNCTION: Probable ATPase involved in the assembly or function of nuclear protein complexes. May also be involved in some aspects of microtubule dynamics.
    SUBUNIT: Interacts directly with CHMT1B and ZFYVE27.
    SUBCELLULAR LOCATION: Nucleus. Cytoplasm, perinuclear region.
    ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing. Name 1
    Isoform ID Q9UBP0-1
    This is the isoform sequence displayed in this entry.
    TISSUE SPECIFICITY: Ubiquitous.
    DISEASE: Defects in SPAST are the cause of spastic paraplegia autosomal dominant type 4 (SPG4) [MIM:182601]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. SPG4 is the most common form of autosomal dominant spastic paraplegias.
    SIMILARITY: Belongs to the AAA ATPase family.
    SIMILARITY: Contains 1 MIT domain.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at 2-8°C for up to 1 year from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MAB5634,Anti-Spastin Antibody, clone Sp3G11/1

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