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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, ELISA, FC, ICC M Purified Monoclonal Antibody 描述 产品目录编号 MAB2144 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-VCAM-1 Antibody, clone P3C4 Alternate Names - CD106
背景信息 This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. 产品信息 格式 Purified 控制 - Immunohistochemistry:
Angiogenesis producing cancers or vascular tissue.
演示 Nonsterile liquid contains 0.02M phosphate buffer, 0.25M sodium chloride, and 0.1% sodium azide. Filtered through 0.45 micron membrane filter. 应用 应用 Detect VCAM-1 using this Anti-VCAM-1 Antibody, clone P3C4 validated for use in ELISA, FC, IP, IC, IH. 主要应用 - Immunohistochemistry
- ELISA
- Flow Cytometry
- Immunocytochemistry
应用说明 Immunohistochemistry: for use on acetone or paraformaldehyde fixed tissue
Immunocytochemistry: for use on HUT 78 and endothelial cells activated with cytokines. VCAM is also expressed on skeletal muscle.
Immunoprecipitation
Flow cytometry
ELISA
Inhibits cell adhesion to IL-1beta1 activated HUVEC
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 IL-1beta activated HUVEC (human) 克隆 P3C4 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 Human VCAM 同种型 IgG1 品种反应性 Human Species Reactivity Note Reacts with human. Other species have not been tested. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_080682.1
- NM_001078.2
Entrez基因汇总 This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. 基因符号 - L1CAM
- VCAM1
- INCAM-100
- MGC99561
- CD106
- DKFZp779G2333
纯化方法 Protein G purfied UniProt编号 - P19320
UniProt汇总 FUNCTION: SwissProt: P19320 # Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
SIZE: 739 amino acids; 81276 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
DOMAIN: SwissProt: P19320 Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
PTM: Sialoglycoprotein.
DISEASE:SwissProt: P19320 # May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.
SIMILARITY: Contains 7 Ig-like C2-type (immunoglobulin-like) domains.产品使用声明 质量保证 Routinely evaluated by immunohistochemistry on ovarian cancer tissue. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at +2-8°C. 包装信息 数量 100 µg
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