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merck millipore,默克密理博,SF-1116,Frataxin; Human, Cyanine 5 RNA Detection Probe,SmartFlare
产品名称：Frataxin; Human, Cyanine 5 RNA Detection Probe, SmartFlare
产品型号：SF-1116
Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare Frataxin, Human, Cyanine 5, you can detect Frataxin RNA levels within your cell More>>
merck millipore,默克密理博,SF-1116,Frataxin; Human, Cyanine 5 RNA Detection Probe,SmartFlare
- 产品介绍
重要规格表
Entrez Gene Number Species Reactivity Species Reactivity Note NM_000144.4 H NM_181425.2, NM_001161706.1 描述 产品目录编号 SF-1116 商名 - SmartFlare
描述 Frataxin; Human, Cyanine 5 RNA Detection Probe | SmartFlare Alternate Names - FA, X25, CyaY
背景信息 With SmartFlare™ RNA Detection probes, you can detect RNA in LIVE CELLS with ease. With just an overnight incubation of Frataxin; Human, Cyanine 5 RNA Detection Probe you can detect the presence of Frataxin within your cells.
Frataxin is a monomeric mitochondrial protein that is believed to be involved in iron homeostasis through an unknown mechanism. Expression of frataxin is highest in tissue rich with mitochondria including liver, heart, and skeletal muscle (Campuzano, 1996; Koutnikova, 1997). Frataxin is expressed as a 30 kDa precursor (transient; 210 amino acids) that is processed within in the mitochondria in two steps catalysed by the mitochondrial processing peptidase (MPP) to yield the mature protein (Koutnikova, 1998). The first step involves cleavage of the first 41 N-terminal amino acids by MPP yielding a transient intermediate of approximately 20 kDa (aa 42-210). Further cleavage of the N-terminus of this 20 kDa intermediate by MPP results in the mature 18 kDa frataxin protein (aa 56-210). Defects in the gene encoding frataxin are implicated as the cause of Friedreich's ataxia, an autosomal recessive, progressive degenerative disease characterized by neurodegeneration and cardiomyopathy. In the majority of cases of Friedreich's ataxia, there is an expansion of a trinucleotide repeat in the first intron of the gene encoding frataxin resulting in a marked decrease in frataxin expression, perhaps due to the formation of some unusual yet stable DNA structure that interferes with transcription (Campuzano, 1997; Bidichandani, 1998). This reduction in frataxin expression results in the accumulation of unchelated iron in the mitochondria, inhibition of mitochondrial iron-sulfer proteins, and iron mediated oxidative stress (Foury, 1997; for review see Puccio, 2000).产品信息 格式 Cyanine 5 演示 Lyophilized 应用 应用 Use SmartFlare RNA Detection probes to measure gene expression in live cells. With an overnight incubation of SmartFlare Frataxin, Human, Cyanine 5, you can detect Frataxin RNA levels within your cells. 主要应用 - RNA Detection
生物信息 品种反应性 Human Species Reactivity Note NM_181425.2, NM_001161706.1 Entrez基因编号 - NM_000144.4
基因符号 - Frataxin
产品使用声明 质量保证 SmartFlare Probes have been tested in a buffer system to detect the release of the fluorophore in the presence of a complimentary base pair sequence for each lot to confirm target specificity. SmartFlare Probes have also been tested in a cell model system and demonstrated increased fluorescence in cells expressing the target compared to a negative SmartFlare Scramble Control. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at 2–8°C in lyophilized format ONLY. Room temperature is required for reconstituted product. 包装信息 数量 250 reactions
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