merck millipore,默克密理愽
  • merck millipore,默克密理博,239822,CXCR4 Antagonist III - Calbiochem

  • merck millipore,默克密理博,239822,CXCR4 Antagonist III - Calbiochem

    产品名称：CXCR4 Antagonist III - Calbiochem
    产品型号：239822
    The CXCR4 Antagonist III controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,239822,CXCR4 Antagonist III - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,239822,CXCR4 Antagonist III - Calbiochem

    重要规格表

    经验配方
    C₃₀H₄₃N₇•2HCl
    描述
    概述 A cell-permeable quinazoline compound that acts as a potent and reversible CXCR4 antagonist (IC50 = 36.2 nM for SDF-1/CXCL12 binding to hCXCR4-transfected HEK293 membrane) with selectivity over closely related human chemokine receptors CXCR2, CCR2, CCR4 and CCR5 (IC50 >10 µM). Shown to inhibit CXCL12-induced Ca2+-mobilization and cell migration in hCXCR4-HEK293 cells (IC50 = 100.1 and 41 nM, respectively), and rapidly mobilize CXCR4+, CD34+ and CD133+ stem cells from bone marrow in C57BL/6 male mice (6 mg/kg, s.c).
    产品目录编号 239822
    品牌系列 Calbiochem®
    同义词 N²-(4-((3-(Cyclohexylamino)propylamino)methyl)benzyl)-N⁴-(piperidin-4-yl) quinazoline-2,4-diamine, 2HCl, Fusin Antagonist III
    参考
    参考 Wu, C.H., et al. 2012. Chem. Med. Chem. 7, In press.
    产品信息
    形式 White solid
    Hill配方 C₃₀H₄₃N₇•2HCl
    化学配方 C₃₀H₄₃N₇•2HCl
    Molar Mass 574.6
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 CXCR4
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,239822,CXCR4 Antagonist III - Calbiochem

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