merck millipore,默克密理愽
  • merck millipore,默克密理博,14-818,Met (D1246N) Protein, active, 10 µg

  • merck millipore,默克密理博,14-818,Met (D1246N) Protein, active, 10 µg

    产品名称：Met (D1246N) Protein, active, 10 µg
    产品型号：14-818
    Active, N-terminal 6His-tagged, recombinant, human, Met amino acids 974-end, containing the mutation D1246N, for use in Kinase Assays.

    merck millipore,默克密理博,14-818,Met (D1246N) Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-818,Met (D1246N) Protein, active, 10 µg

    描述
    产品目录编号 14-818
    品牌系列 Upstate
    商名
    • Upstate
    描述 Met (D1246N) Protein, active, 10 µg
    概述 N-terminal 6His-tagged, recombinant, human, Met amino acids 974-end, containing the mutation D1246N
    背景信息 Met D1246N is a germline mutation that has been identified in patients with hereditary papillary renal carcinomas (HPRC). In vitro studies have demonstrated enhanced kinase activity from this mutant.
    应用
    应用 Active, N-terminal 6His-tagged, recombinant, human, Met amino acids 974-end, containing the mutation D1246N, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • The recombinant protein contains the amino acid substitutions A1209G and V1290L with reference to GenBank J02958. Both substitutions are reported in GenBank BU595386, BQ315895 and BQ316491.
    • J02958
    Entrez基因汇总 The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.
    基因符号
    • HGFR
    • MET
    • AUTS9
    • c-Met
    • RCCP2
    蛋白靶 Met
    纯化方法 Ni2+/NTA-agarose
    靶子系列 TK
    UniProt编号
    • P08581
    UniProt汇总 FUNCTION: SwissProt: P08581 # Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity.
    SIZE: 1390 amino acids; 155527 Da
    SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    DISEASE: SwissProt: P08581 # Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. & Defects in MET may be associated with gastric cancer. & Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. & Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance. & Genetic variations in MET may be associated with susceptibility to autism type 1B (AUTS1B) [MIM:608636]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.
    SIMILARITY: SwissProt: P08581 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 3 IPT/TIG domains. & Contains 1 protein kinase domain. & Contains 1 Sema domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg
    包装 Available in 250 μg --call for pricing and availability and reference catalog number 14-818M when ordering the 250 μg size.

    merck millipore,默克密理博,14-818,Met (D1246N) Protein, active, 10 µg

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