merck millipore,默克密理愽
  • merck millipore,默克密理博,04-393,Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit monoclonal

  • merck millipore,默克密理博,04-393,Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit monoclonal

    产品名称：Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit monoclonal
    产品型号：04-393
    This Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit is validated for use in IP, WB for the detection of phospho-p70 S6 Kinase (Thr421/Ser424).

    merck millipore,默克密理博,04-393,Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit monoclonal

  • 产品介绍
  • merck millipore,默克密理博,04-393,Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit monoclonal

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbPurifiedMonoclonal Antibody
    描述
    产品目录编号 04-393
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit monoclonal
    Alternate Names
    • RPS6KB1 ribosomal protein S6 kinase, 70kDa, PS6K, S6K, S6K1, STK14A, p70(S6K)-alpha, p70-S6K, p70-alpha
    • RPS6KB1 ribosomal protein S6 kinase
    • 70kDa
    • PS6K
    • S6K
    • S6K1
    • STK14A
    • p70(S6K)-alpha
    • p70-S6K
    产品信息
    格式 Purified
    演示 100 μL of rabbit monoclonal IgG in 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
    应用
    应用 This Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit is validated for use in IP, WB for the detection of phospho-p70 S6 Kinase (Thr421/Ser424).
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 KLH-conjugated synthetic peptide corresponding to the region surrounding Thr421 and Ser424 of human p70 S6 Kinase.
    宿主 Rabbit
    特异性 Recognizes the p70 S6 Kinase when phosphorylated on Thr421 and Ser424.
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note Not believed to react with mouse or rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_003161.2
    Entrez基因汇总 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
    基因符号
    • PS6K
    • RPS6KB1
    • p70-alpha
    • p70S6k
    • p70-S6K
    • p70
    • S6K
    • S6Kalpha)
    • P70S6K
    • STK14A
    • S6K1
    • p70(S6K)-alpha
    修改
    • Phosphorylation
    UniProt编号
    • P23443
    UniProt汇总 FUNCTION: SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.
    SIZE: 525 amino acids; 59140 Da
    SUBUNIT: Interacts with PPP1R9A/neurabin-1 (By similarity).
    SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity).
    TISSUE SPECIFICITY: Widely expressed.
    SIMILARITY: SwissProt: P23443 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C from date of shipment
    包装信息
    数量 100 µL

    merck millipore,默克密理博,04-393,Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit monoclonal

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