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merck millipore,默克密理博,MABT409,Anti-Integrin Beta1, clone AIIB2 (Azide Free) Antibody
产品名称：Anti-Integrin Beta1, clone AIIB2 (Azide Free) Antibody
产品型号：MABT409
This Anti-Integrin Beta1, clone AIIB2 (Azide Free) Antibody is validated for use in Western Blotting and Immunocytochemistry and Activity Assay and Immunoprecipitation and Immunohistochemistry for the More>>
merck millipore,默克密理博,MABT409,Anti-Integrin Beta1, clone AIIB2 (Azide Free) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Rhesus Macaque, H, B, Po, Sh, Eq, Ca IHC, WB, ICC, ACT R Purified Monoclonal Antibody 描述 产品目录编号 MABT409 描述 Anti-Integrin Beta1, clone AIIB2 (Azide Free) Antibody Alternate Names - CD29
- VLA-4 subunit beta
- GPIIA
- Glycoprotein Iia
- Fibronectin receptor subunit beta
- Integrin beta-1
背景信息 Integrin beta-1, also known as Fibronectin receptor subunit beta (FNRB), and Glycoprotein IIa (GPIIA), is a transmembrane glycoprotein that forms noncovalent complexes with various alpha integrin subunits to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumor cells. Interactions between integrins and extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. Phosphorylation of threonines 788 and 789 on integrin beta1 receptor may play a key role in cell-cycle dependent regulation. 产品信息 格式 Purified 演示 Purified rat monoclonal IgG1κ in buffer containing PBS without preservatives. 应用 应用 This Anti-Integrin Beta1, clone AIIB2 (Azide Free) Antibody is validated for use in Western Blotting and Immunocytochemistry and Activity Assay and Immunoprecipitation and Immunohistochemistry for the detection of Integrin Beta1. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
- Activity Assay
应用说明 Activity Assay Analysis: A representative lot detected Integrin Beta1, clone AIIB2 (Azide Free) in this functionally blocking antibody abrogated AGS cell attachment to fibronectin while causing only a slight inhibition of cell attachment to vitronectin (Hutton, M., et. al. (2010). Infection and Immunity. 78(11):4523-4531).
Immunohistochemistry Analysis: A representative lot detected Integrin Beta1, clone AIIB2 (Azide Free) in floating villi tissue (Damsky, C. H., et al. (1992). Journal of Clinical Investigation. 89:210-222).
Immunohistochemistry Analysis: A representative lot detected Integrin Beta1, clone AIIB2 (Azide Free) in CTB aggregates that have invaded matrigel in vitro (Damsky, C. H., et al. (1994). Development. 120:3657-3666).
Immunocytochemistry Analysis: A representative lot detected Integrin Beta1, clone AIIB2 (Azide Free) in AGS cells (Hutton, M., et. al. (2010). Infection and Immunity. 78(11):4523-4531).
Immunoprecipitation Analysis: A representative lot immunoprecipitated Integrin Beta1, clone AIIB2 (Azide Free) in NP-40 cell lysate (Werb, Z., et al. (1989). JCB. 109:877-889).生物信息 免疫原品种 Whole cells corresponding to human Integrin Beta1, clone AIIB2 (Azide Free). 克隆 AIIB2 浓缩 1 mg/mL 宿主 Rat 同种型 IgG1κ 品种反应性 Rhesus MacaqueHumanBovinePigSheepHorseCanine Species Reactivity Note Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002202
基因符号 - MSK12
- ITGB1
- FNRB
- MDF2
纯化方法 Protein G purified UniProt编号 - P05556
产品使用声明 质量保证 Evaluated by Western Blotting in HUVEC cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Integrin Beta1, clone AIIB2 (Azide Free) in 10 µg of HUVEC cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µg
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