merck millipore,默克密理博,IHCR1013-6,Anti-Calbindin D-28K Antibody, prediluted

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	IH(P)	Rb	Purified	Polyclonal Antibody

描述
产品目录编号	IHCR1013-6
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Calbindin D-28K Antibody, prediluted
背景信息	Calbindin D28k is a member of a large family of intracellular calcium-binding proteins of the EF-hand related to calmodulin and troponin-C. The biological roles of Calbindin D28k include, calcium regulation (including calcium transport and uptake, calcification of bone and teeth) and calcium related signalling in neurons and transiently in embryological development. This calbindin also has a role in protecting neurons from apoptotic cell death. Disregulation of this calbindin protein relates to several disease states. Decline in calbindin D28k in hippocampal dentate granule cells correlates with the kindling model for epilepsy. Calbindin D28k immunoreactivity is specifically absent from neuronal poplulations lost early in ALS, while substantial loss of neurons which do contain the protein occur in patients with Huntington's disease.

产品信息
格式	Purified
演示	Liquid diluted in PBS, pH 7.2 with stabilizers, 0.2% Tween 20, and 0.1% ProClin 300 as preservative.

应用
应用	Detect Calbindin D-28K using this Anti-Calbindin D-28K Antibody, prediluted validated for use in IH(P).
主要应用	Immunohistochemistry (Paraffin)
应用说明	Antibody is prediluted and ready to use for Immunohistochemistry of formalin-fixed, paraffin-embedded tissues. Pretreatment: Heat Induced Epitope Retrieval (HIER). Recommend Citrate Buffer, pH 6.0 (Cat. No. 21545). No signal was detected without Epitope retrieval. Incubation: 30 minutes with IHC Select® Detection Kits. Calbindin has been prediluted for use as the primary antibody with Chemicon's IHC Select® Detection Kits and Protocols (Catalog Nos. DAB050, DET-HP1000, APR050, and DET-APR1000), but other supplier's IHC detection systems may be used.

生物信息
免疫原品种	Purified recombinant calbindin.
宿主	Rabbit
特异性	Calbindin. Shows no cross-reactivity to calretinin by Western blot. The antibody produces specific staining of cerebellum Purkinje cells, molecular layer dendrites and axonal fibers, stains cell bodies and fibers in neuronal subpopulations.
品种反应性	Human
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_004929.2
Entrez基因汇总	Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It was originally described as a 27-kD protein induced by vitamin D in the duodenum of the chick. In the brain, its synthesis is independent of vitamin-D-derived hormones. Calbindin contains 4 active calcium-binding domains, and 2 modified domains that presumably have lost their calcium-binding capacity. The neurons in brains of patients with Huntington disease are calbindin-depleted.
基因符号	Calbindin CALB1 D-28K CALB CAB27
UniProt编号	P05937
UniProt汇总	FUNCTION: SwissProt: P05937 # Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. SIZE: 261 amino acids; 30025 Da SUBUNIT: Interacts with RANBP9. DOMAIN: SwissProt: P05937 This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium. SIMILARITY: Belongs to the calbindin family. & Contains 5 EF-hand domains.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at 2-8oC. Refer to vial for expiration dating.

包装信息
数量	6 mL

merck millipore,默克密理博,IHCR1013-6,Anti-Calbindin D-28K Antibody, prediluted

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