merck millipore,默克密理博,04-589,Anti-Calponin-1 (CT) Antibody, rabbit monoclonal, clone EP798Y

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	ICC, WB	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-589
品牌系列	Upstate
商名	Upstate
描述	Anti-Calponin-1 (CT) Antibody, rabbit monoclonal, clone EP798Y
背景信息	Calponin is a smooth muscle specific, actin-, tropomyosin- and calmodulin-binding protein thought to be involved in regulation of actomyosin as well as the regulation or modulation of contraction (1). Calponin binds filamentous actin (F-actin) through two distinct sites ABS1 and ABS2, with an affinity in the low micromolar range (2) Immunoreactivity for calponin, along with alpha-smooth muscle actin and smooth muscle myosin heavy chains, confirms the known neoplastic myoepithelial component of adenoid cystic carcinomas and epithelial-myoepithelial carcinomas. The consistently positive staining pattern in adenoid cystic carcinomas may be diagnostically useful in discriminating histologically similar but consistently negative polymorphous low-grade adenocarcinomas (3).

产品信息
格式	Purified
演示	Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect Calponin-1 (C-Term) using this Anti-Calponin-1 (C-Term) Antibody, Rabbit, clone EP798Y validated for use in WB, IC, IH(P).
主要应用	Immunocytochemistry Western Blotting
应用说明	WB: 1:20,000 IHC: 1:100 - 250 (Paraffin-embedded human smooth muscle) ICC: 1:100 - 250 (Hela cells)

生物信息
免疫原品种	A synthetic peptide corresponding to residues near the C-term of human Calponin.
克隆	EP798Y
宿主	Rabbit
特异性	Recognizes Human, Mouse, Rat Calponin-1 (C-Term).
品种反应性	RatHumanMouse
Species Reactivity Note	Human, Mouse, Rat (positive control: human bladder lysate)
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_001299.4
基因符号	Calponin-1 CNN1 SMCC Sm-Calp
纯化方法	Protein A purfied
UniProt编号	P51911
UniProt汇总	FUNCTION: SwissProt: P51911 # Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). SIZE: 297 amino acids; 33170 Da SUBUNIT: Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). TISSUE SPECIFICITY: Smooth muscle, and tissues containing significant amounts of smooth muscle. SIMILARITY: SwissProt: P51911 ## Belongs to the calponin family. & Contains 3 calponin-like repeats. & Contains 1 CH (calponin-homology) domain.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Store at -20 °C. Stable for 12 months from date of receipt.

包装信息
数量	100 µL

merck millipore,默克密理博,04-589,Anti-Calponin-1 (CT) Antibody, rabbit monoclonal, clone EP798Y

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