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描述 产品目录编号 14-528M 品牌系列 Upstate
商名 - Upstate
描述 MEK2 Protein, active, 250 µg 概述 N-terminal His6-tagged recombinant, full-length human MEK2 应用 应用 Active, N-terminal His6-tagged recombinant, full-length human MEK2, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed by baculovirus in Sf21 insect cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_030662.2
Entrez基因汇总 The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax. 基因符号 - MKK2
- MAP2K2
- PRKMK2
- MAPKK2
- MEK2
蛋白靶 MEK2 纯化方法 Ni2+/NTA-agarose 靶子系列 STE UniProt编号 - P36507
UniProt汇总 FUNCTION: SwissProt: P36507 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).
SIZE: 400 amino acids; 44424 Da
SUBUNIT: Interacts with MORG1 (By similarity).
PTM: MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).
DISEASE: SwissProt: P36507 # Defects in MAP2K2 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio- cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.
SIMILARITY: SwissProt: P36507 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of unactive MAP Kinase 2/Erk2 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-528) and in bulk (cat# 14-528-K).
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