merck millipore,默克密理愽
  • merck millipore,默克密理博,124013,Akt Inhibitor VI, Akt-in - Calbiochem

  • merck millipore,默克密理博,124013,Akt Inhibitor VI, Akt-in - Calbiochem

    产品名称：Akt Inhibitor VI, Akt-in - Calbiochem
    产品型号：124013
    The Akt Inhibitor VI, Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,124013,Akt Inhibitor VI, Akt-in - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,124013,Akt Inhibitor VI, Akt-in - Calbiochem

    重要规格表

    经验配方
    C₈₈H₁₂₃N₂₃O₂₃
    描述
    概述 A reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction, thus hindering membrane translocation from the cytosol and downstream biological responses.
    产品目录编号 124013
    品牌系列 Calbiochem®
    同义词 TCL1₁₀₋₂₄, H-AVTDHPDRLWAWEKF-OH
    参考
    参考 Hiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.
    产品信息
    具有ATP竞争性 N
    形式 White lyophilized solid
    配方 Supplied as an acetate salt.
    Hill配方 C₈₈H₁₂₃N₂₃O₂₃
    化学配方 C₈₈H₁₂₃N₂₃O₂₃
    Molar Mass 1871.1
    吸湿 Hygroscopic
    肽序列 H-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
    可逆 Y
    生物信息
    主靶 Akt
    主靶IC50 Kd ~18 µM in binding to Akt-PH domain
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 H₂O
    肽序列 H-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,124013,Akt Inhibitor VI, Akt-in - Calbiochem

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