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描述 产品目录编号 ALP20 品牌系列 Chemicon®
商名 - Chemicon
描述 Apolipoprotein A-II, human 概述 High Density Lipoprotein (HDL) isolated by sequential isopycnic ultracentrifugation are delipidated. Apo A-II is purified by column chromatography in 6M urea (Schonfeld et al. 1977). Purity is determined by quantitative densitometry of SDS polyacrylamide gels (Laemlli 1970). Protein is determined by the Pierce BCA method (which was found to be comparable to the Lowry method) with 1% BSA as the standard. Apo A-II, which is a dimer composed of identical subunits, has a Mr of 17 kD and a pI of 4.9. Apo-II activates hepatic lipase and inhibits LCAT. Apolipoproteins are soluble in aqueous solutions. However, due to its amphipathic structure Apo-II self-associates into oligomers at high protein concentrations. Apo A-II exists as dimers in buffers with 5M guanidine-HCL or 6M urea.
MOLECULAR WEIGHT:
17,400Alternate Names - ApoAII
产品信息 演示 Liquid in 10 mM NH4HCO3, pH 7.4. Non-sterile, no preservatives. 应用 主要应用 - Positive Control
生物信息 浓缩 4.89 mg/mL 纯度 > 98% 来源 Normal human plasma, fresh, non-frozen. Tested negative for HIV-1, HIV-2, HCV and HBc antibodies and HBsAg. 品种 Human Entrez基因编号 - NM_001643.1
Entrez基因汇总 This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. 基因符号 - Apo-AII
- APOA2
- ApoA-II
UniProt编号 - P02652
UniProt汇总 FUNCTION: SwissProt: P02652 # May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
SIZE: 100 amino acids; 11175 Da
SUBUNIT: Homodimer; disulfide-linked. Also forms a disulfide- linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Plasma; synthesized in the liver and intestine.
SIMILARITY: SwissProt: P02652 ## Belongs to the apolipoprotein A2 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at < -20°C for up to six months. Maintain reconstituted Apo A-II at +4°C for up to 4 weeks. Freezing solutions of apolipoproteins in the absence of denaturants may favor increased self-association or aggregation. 包装信息 数量 500 µg
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