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描述 产品目录编号 14-728M 品牌系列 Upstate
商名 - Upstate
描述 Mer Protein, active, 250 µg 概述 N-terminal GST-tagged, recombinant, human Mer, amino acids 557-882 应用 应用 Active, N-terminal GST-tagged, recombinant, human Mer, amino acids 557-882, for use in Kinase Assays. 主要应用 - Kinase Assay
生物信息 来源 expressed by baculovirus in Sf21 cells 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. Entrez基因编号 - NM_006343.2
Entrez基因汇总 This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). 基因符号 - MER-PEN
- MERTK
- MGC133349
- c-mer
- mer
- MER
蛋白靶 Mer 纯化方法 Glutathione-agarose 靶子系列 TK UniProt编号 - Q12866
UniProt汇总 SIZE: 999 amino acids; 110249 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
TISSUE SPECIFICITY: Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.
DISEASE: SwissProt: Q12866 # Defects in MERTK are a cause of retinitis pigmentosa (RP) [MIM:268000]. RP that leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
SIMILARITY: SwissProt: Q12866 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. & Contains 2 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.产品使用声明 质量保证 routinely evaluated by phosphorylation of 250μM substrate peptide (GGMEDI 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 6 months at -70°C from date of shipment 包装信息 数量 250 µg 包装 Also available in 10 μg size (cat#14-728) and in bulk (cat# 14-728-K).
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