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描述 概述 Native tissue plasminogen activator from a human melanoma cell line. A serine protease that contains a single chain of 527 amino acids. Binds to fibrin via lysine binding sites at its amino terminus and activates bound plasminogen. Cleaves plasminogen to form active plasmin, the proteolytic enzyme that dissolves clots. Reported to be involved in neurite outgrowth, regeneration, and migration. Plays an important role in excitotoxin-induced neuronal degeneration. 产品目录编号 612200 品牌系列 Calbiochem®
同义词 tPA 参考 参考 Kim, Y.H., et al. 1999. Science 284, 647.
Tsirka, S.E., et al. 1995. Nature 377, 340.
Winther, K., et al. 1992. J. Cardiovasc. Pharmacol. 19, S21.产品信息 形式 Lyophilized 配方 Lyophilized from 100 mM PBS, 3.5 mg/ml L-arginine, 0.001% Tween®-80 Detergent. Molar Mass 65000 生物信息 纯度 ≥95% by SDS-PAGE 来源 Prepared from cell line that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. 特异活性 ≥300 KU/mg protein 理化信息 溶解度 dH₂O 储存和货运信息 货运代码 Blue Ice Only
毒性 Standard Handling
储存 -20°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
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