merck millipore,默克密理博,688001,InSolution™ Y-27632

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Merck Millipore 默克密理愽

merck millipore,默克密理博,688001,InSolution™ Y-27632 - Calbiochem

经验配方
C₁₄H₂₁N₃O · 2HCl · H₂O

描述
概述	A highly potent, cell-permeable, selective inhibitor of Rho-associated protein kinase (K_i = 140 nM for p160^ROCK (ROCK-I). Also inhibits ROCK-II with almost equal potency. Inhibition is achieved by competing with ATP for binding to the catalytic site. Exhibits 10- to 50-fold lower affinity for PKC_ε than p160^ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at high concentrations (~100 mM). Also acts as a potent inhibitor of agonist-induced Ca²⁺ sensitization of myosin phosphorylation and smooth muscle contractions (IC₅₀ = 700 nM for phenylephrine-induced contractions in aortic strips).
产品目录编号	688001
品牌系列	Calbiochem®
同义词	Rho Kinase Inhibitor VI

参考
参考	Chitaley, K., et al. 2001. Nat. Med. 7, 119. Davies, S.P., et al. 2000. Biochem. J. 351, 95. Narumiya, S., et al. 2000. Methods Enzymol. 325, 273. Hirose, M., et al. 1999. J. Cell Biol. 141, 1625. Maekawa, M., et al. 1999. Science 285, 895. Uehata, M., et al. 1997. Nature 389, 990.

产品信息
具有ATP竞争性	Y
声明	Sold under license of PCT Application W098/06,433A1 and under license from Mitsubishi Pharma Tanabe Corporation.
形式	Liquid
配方	A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688000) in H₂O.
Hill配方	C₁₄H₂₁N₃O · 2HCl · H₂O
化学配方	C₁₄H₂₁N₃O · 2HCl · H₂O
Molar Mass	338.3
可逆	N
结构配方图像

生物信息
主靶	p160ROCK
主靶IC₅₀	700 nM against phenylephrine-induced contractions in aortic strips
主靶K_i	140 nM for p160ROCK (ROCK-I)
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y

安全信息
R相	R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
S相	S: 36 Wear suitable protective clothing.

储存和货运信息
货运代码	Blue Ice Only
毒性	Harmful
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following initial thaw, aliquot and freeze (-20°C).

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,688001,InSolution™ Y-27632 - Calbiochem

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