merck millipore,默克密理愽
  • merck millipore,默克密理博,616521,TRPV4 Antagonist II, HC-067047 - Calbiochem

  • merck millipore,默克密理博,616521,TRPV4 Antagonist II, HC-067047 - Calbiochem

    产品名称：TRPV4 Antagonist II, HC-067047 - Calbiochem
    产品型号：616521
    The TRPV4 Antagonist II, HC-067047 controls the biological activity of TRPV4.

    merck millipore,默克密理博,616521,TRPV4 Antagonist II, HC-067047 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,616521,TRPV4 Antagonist II, HC-067047 - Calbiochem

    重要规格表

    经验配方
    C₂₆H₂₈F₃N₃O₂
    描述
    概述 A pyrrolocarboxamide compound that potently antagonizes TRP (transient receptor potential) family cation channel TRPV4 activity (IC50 = 17, 48, and 133 nM, respectively, against mouse, human, or rat TRPV4 in whole cell voltage-gated current measurement) in a reversible manner, displaying much reduced potency against human ERG and TRPM8 (IC50 = 368 and 780 nM, respectively) and little or no activity toward hKv1.3, hTRPA1, hTRPC5, hTRPV1/2/3/6, mTRPM7, mTRPV2, or rKv1.2. HC-067047 is efficacious (10 mg/kg via i.p.) in reducing micturition (urination) frequency and increasing voided urine volume of mice and rats suffering from CPA- (Cat. No. 239785) induced cystitis in vivo.
    产品目录编号 616521
    品牌系列 Calbiochem®
    同义词 2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II, HC067047
    参考
    参考 Everaerts, W., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 19084.
    产品信息
    形式 White solid
    Hill配方 C₂₆H₂₈F₃N₃O₂
    化学配方 C₂₆H₂₈F₃N₃O₂
    Molar Mass 471.5
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,616521,TRPV4 Antagonist II, HC-067047 - Calbiochem

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