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merck millipore,默克密理博,217531,CARM1 Inhibitor - Calbiochem
产品名称：CARM1 Inhibitor - Calbiochem
产品型号：217531
The CARM1 Inhibitor controls the biological activity of CARM1. This small molecule/inhibitor is primarily used for Cell Structure applications.
merck millipore,默克密理博,217531,CARM1 Inhibitor - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₆H₂₁Br₂NO₃ 描述 概述 A cell-permeable (bis-benzylidene)piperidinone compound that acts as a selective inhibitor against CARM1/PRMT4 arginine methyltransferase activity (IC50 = 7.1 µM with PABP1 as substrate). It inhibits PRMT3 only at much higher concentrations (by 70% and 62% with 100 µM inhibitor using NPL3 or rpS2 as substrate, respectively), exhibiting little activity against PRMT1, PRMT5, PRMT6 (IC50 >100 µM), or four HKMTs (<20% inhibition against DOTL1, G9a, SET7, or Suv39H1 with 100 µM inhibitor). Shown to inhibit PSA promoter-mediated reporter transcription in LNCaP cells in a dose-dependent manner (by 74% and 97%, respectively, with 4 and 6 µM inhibitor). 产品目录编号 217531 品牌系列 Calbiochem®
同义词 Coactivator-Associated Arginine Methyltransferase 1 Inhibitor, 1-Benzyl-3,5-bis-(3-bromo-4-hydroxybenzylidene)piperidin-4-one, 3,5-bis(3-Bromo-4-hydroxybenzylidene)-1-benzylpiperidin-4-one, PRMT Inhibitor V 参考 参考 Cheng, D., et al. 2011. J. Med. Chem. 54, 4928. 产品信息 形式 Orange solid Hill配方 C₂₆H₂₁Br₂NO₃ 化学配方 C₂₆H₂₁Br₂NO₃ Molar Mass 555.3 可逆 Y 结构配方图像 生物信息 主靶 PRMT4 主靶IC50 CARM1-mediated methylation over PRMT1 and SET7 (IC₅₀ = 7.1, 63 and 943 µM, 副靶 SET7 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,07-2148,Anti-Rho GTPase-activating protein 27 Antibody
下一件merck millipore产品：merck millipore,默克密理博,616521,TRPV4 Antagonist II, HC-067047 - Calbiochem
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