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merck millipore,默克密理博,428150,Lavendustin A - CAS 125697-92-9 - Calbiochem
产品名称:Lavendustin A - CAS 125697-92-9 - Calbiochem
产品型号:428150
A cell-permeable, reversible, and substrate competitive inhibitor of EGF receptor tyrosine kinase and p60c-src with little effect on protein kinase A or protein kinase C.
merck millipore,默克密理博,428150,Lavendustin A - CAS 125697-92-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₁H₁₉NO₆ 125697-92-9 描述 概述 A cell-permeable, reversible, and substrate competitive inhibitor of EGF receptor tyrosine kinase (IC50 = 11 nM) and p60c-src (IC50 = 500 nM) with little effect on protein kinase A or protein kinase C (IC50 > 200 µM). Also inhibits NMDA-stimulated cGMP production (IC50 = 30 nM). Exhibits anti-proliferative properties. Suppresses the angiogenic action of vascular endothelial growth factor (VEGF) in rats. 产品目录编号 428150 品牌系列 Calbiochem®
同义词 5-Amino-[(N-2,5-dihydroxybenzyl)-Nʹ-2-hydroxybenzyl]salicylic Acid, RG14355 参考 参考 Hu, D.E., and Fan, T.-P. 1995. Br. J. Pharmacol. 114, 262.
Rodriguez, J., et al. 1994. Neuropharmacology 33, 1267.
Hsu, C.-Y., et al. 1991. J. Biol. Chem. 266, 21105.
O’Dell, T.J., et al. 1991. Nature 353, 558; Onoda, T., et al. 1989. J. Nat. Prod. 52, 1252.
Bishop, J.M. 1983. Annu. Rev. Biochem. 52, 307.产品信息 CAS号 125697-92-9 具有ATP竞争性 N 形式 Off-white solid Hill配方 C₂₁H₁₉NO₆ 化学配方 C₂₁H₁₉NO₆ Molar Mass 381.4 可逆 Y 结构配方图像 生物信息 主靶 EGF receptor tyrosine kinase 主靶IC50 11 nM and 500 nM against EGF receptor tyrosine kinase and p60c-src, respectively 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 acetic acid, DMSO, or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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