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merck millipore,默克密理博,420147,JNK Inhibitor XIV, SR-3306 - Calbiochem
产品名称：JNK Inhibitor XIV, SR-3306 - Calbiochem
产品型号：420147
The JNK Inhibitor XIII, SR-3306 controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,420147,JNK Inhibitor XIV, SR-3306 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₈H₂₆N₈O 描述 概述 A cell-permeable, blood-brain-barrier-permeant, and orally available anilinopyrimidine compound that acts as a highly selective, potent, reversible, and ATP-competitive JNK inhibitor (IC50 = 67, 283, and 159 nM against JNK1, JNK2, and JNK3, respectively), exhibiting little or no activity toward a panel of more than 300 kinases, including p38 (IC50 >20 µM). Shown to inhibit c-jun phosphorylation both in STZ- (Streptozotocin, Cat. No. 572201) stimulated INS-1 β-pancreatic cells in vitro (IC50 = 216 nM) and in SNpc (substantia nigra pars compacta) TH- (tyrosine hydroxylase) positive neurons (by 75%; single p.o. dose of 30 mg/kg) from MPTP- (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) treated mice in vivo. Effectively protects against SNpc TH-positive dopaminergic neuron loss in mice (46% vs. 27% loss with vehicle or 30 mg/kg SR-3306; p.o. b.i.d.) and rats (6-fold increase of vehicle control cell count; 10 mg/kg/day; s.c.) due to MPTP and 6-OHDA- (6-hydroxydopamine) intoxication, respectively, in vivo. 产品目录编号 420147 品牌系列 Calbiochem®
同义词 N-(4-(3-(6-Methylpyridin-3-yl)-1H-1,2,4-triazol-1-yl)phenyl)-4-(3-morpholinophenyl)pyrimidin-2-amine 参考 参考 Chambers, J.W., et al. 2011. ACS Chem Neurosci. 2, 198.
Crocker, C.E., et al. 2011. ACS Chem. Neurosci. 2, 207.产品信息 形式 Pale yellow powder Hill配方 C₂₈H₂₆N₈O 化学配方 C₂₈H₂₆N₈O Molar Mass 490.6 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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