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merck millipore,默克密理博,MAB3520,Anti-Ubiquitin Activating Enzyme E1 Antibody, clone 2G2.3
产品名称：Anti-Ubiquitin Activating Enzyme E1 Antibody, clone 2G2.3
产品型号：MAB3520
Anti-Ubiquitin Activating Enzyme E1 Antibody, clone 2G2.3 detects level of Ubiquitin Activating Enzyme E1 & has been published & validated for use in IP, WB, IH.
merck millipore,默克密理博,MAB3520,Anti-Ubiquitin Activating Enzyme E1 Antibody, clone 2G2.3
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB3520 Replaces 05-624 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Ubiquitin Activating Enzyme E1 Antibody, clone 2G2.3 背景信息 The proteosome has long been thought of as the default mechanism for waste elimination within the cell. Recently, however, the proteosome has been recognized as an essential organelle necessary for the processing of antigens, the transcription factor NFkB and other proteins as well. Central to the function of the proteosome is the ubiquitinization of target proteins by a number of unique ubiquitin activation enzymes. 产品信息 格式 Purified 演示 Liquid. Buffer = 0.02 M Phosphate buffer, 0.25 M NaCl, pH 7.6, with 0.1% sodium azide. 应用 应用 Anti-Ubiquitin Activating Enzyme E1 Antibody, clone 2G2.3 detects level of Ubiquitin Activating Enzyme E1 & has been published & validated for use in IP, WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Western blot: 2-4 μg/mL
Immunohistochemistry
Immunoprecipitation
Sero-depletion
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Ubiquitin activating enzyme E1. 克隆 2G2.3 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The antibody specifically binds to ubiquitin activation enzyme E1. The antibody does not inhibit the enzymatic activity of E1. 同种型 IgG1 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_153280.1
- NM_003334.2
Entrez基因汇总 The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. 基因符号 - GXP1
- UBA1
- UBE1X
- MGC4781
- A1S9T
- UBA1A
- A1S9
- UBE1
- A1ST
UniProt编号 - P22314
UniProt汇总 FUNCTION: SwissProt: P22314 # Activates ubiquitin by first adenylating with ATP its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.
SIZE: 1058 amino acids; 117849 Da
SUBUNIT: Monomer (By similarity).
SIMILARITY: SwissProt: P22314 ## Belongs to the ubiquitin-activating E1 family.
MISCELLANEOUS: There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C in undiluted aliquots for up to 6 months. 包装信息 数量 100 µg
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