merck millipore,默克密理愽
  • merck millipore,默克密理博,100109,AACOCF₃ - CAS 149301-79-1 - Calbiochem

  • merck millipore,默克密理博,100109,AACOCF₃ - CAS 149301-79-1 - Calbiochem

    产品名称：AACOCF₃ - CAS 149301-79-1 - Calbiochem
    产品型号：100109
    A cell-permeable trifluoromethyl ketone analog of arachidonic acid.

    merck millipore,默克密理博,100109,AACOCF₃ - CAS 149301-79-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,100109,AACOCF₃ - CAS 149301-79-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₃₁F₃O149301-79-1
    描述
    概述 A cell-permeable trifluoromethyl ketone analog of arachidonic acid. Potent and selective slow-binding inhibitor of cytosolic (85 kDa) phospholipase A2 (cPLA2; IC50 = ~20 µM). Specific inhibition of cPLA2 activity by AACOCF3 partially inhibits TNF-induced apoptosis without inhibition of caspase activity. Causes a significant diminution in thromboxane B2 production in thrombin-stimulated platelets. Also inhibits platelet aggregation in response to collagen and arachidonic acid.
    产品目录编号 100109
    品牌系列 Calbiochem®
    同义词 Arachidonyltrifluoromethyl Ketone, cPLA2α Inhibitor II
    参考
    参考 Almeida T., et al. 1999. Brain Res. 826, 104.
    Kuwata, H., et al. 1998. J. Biol. Chem. 273, 1733.
    Wissing, D., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 5073.
    McNicol, A., and Nickolaychuk, B.R. 1995. Biochem. Pharmacol. 50, 1795.
    Bartoli, F., et al. 1994. J. Biol. Chem. 269, 15625.
    Street, I.P., et al. 1993. Biochemistry 32, 5935.
    产品信息
    CAS号 149301-79-1
    具有ATP竞争性 N
    形式 Clear yellow oil
    Hill配方 C₂₁H₃₁F₃O
    化学配方 C₂₁H₃₁F₃O
    Molar Mass 356.5
    可逆 N
    结构配方图像
    生物信息
    主靶 cPLA2
    主靶IC50 20 µM inhibiting cytosolic (85 kDa) phospholipase A2 (cPLA2)
    纯度 ≥97% by TLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    安全信息
    R相 R: 11

    Highly flammable.
    S相 S: 16-7

    Keep away from sources of ignition - No Smoking.
    Keep container tightly closed.
    储存和货运信息
    货运代码 Dry Ice Only
    毒性 Flammable
    储存 ≤ -70°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for 1-2 months at -20°C or -70°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,100109,AACOCF₃ - CAS 149301-79-1 - Calbiochem

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