- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,324840,EGFR/ErbB-2/ErbB-4 Inhibitor - CAS 881001-19-0 - Calbiochem
产品名称：EGFR/ErbB-2/ErbB-4 Inhibitor - CAS 881001-19-0 - Calbiochem
产品型号：324840
The EGFR/ErbB-2/ErbB-4 Inhibitor, also referenced under CAS 881001-19-0, controls the biological activity of EGFR/ErbB-2/ErbB-4. This small molecule/inhibitor is primarily used for Phosphorylation & D More>>
merck millipore,默克密理博,324840,EGFR/ErbB-2/ErbB-4 Inhibitor - CAS 881001-19-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₇H₁₁ClFN₅O•2.5H₂O 881001-19-0 描述 概述 A cell-permeable, ATP-binding site-targeting alkynamidopyrimidine compound that acts as a potent and irreversible inhibitor of erbB activities (IC50 = 0.3, 1.1, and 0.5 nM for erbB-1, erbB-2, and erbB-4, respectively). Inhibits EGF- and heregulin-induced erbB autophosphorylation in NIH3T3-erbB-1 and in MDA-MB-453 cells (IC50 = 2.5 and 24 nM, respectively). 产品目录编号 324840 品牌系列 Calbiochem®
同义词 N-(4-((3-Chloro-4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-6-yl)2-butynamide 参考 参考 Klutchko, S.R., et al. 2006. J. Med. Chem. 49, 1475. 产品信息 CAS号 881001-19-0 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₁₇H₁₁ClFN₅O•2.5H₂O 化学配方 C₁₇H₁₁ClFN₅O•2.5H₂O Molar Mass 400.8 可逆 N 结构配方图像 生物信息 主靶 EGFR/ErbB-2/ErbB-4 主靶IC50 0.3, 1.1, and 0.5 nM for erbB-1, erbB-2, and erbB-4, respectively; 2.5 and 24 nM against EGF- and heregulin-induced erbB autophosphorylation in NIH3T3-erbB-1 and in MDA-MB-453 cells, respectively 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,05-1064,Anti-Phospho-Stat1 (Tyr701) Antibody, clone 5C9.2
下一件merck millipore产品：merck millipore,默克密理博,MAB3560,Anti-8-Oxoguanine Antibody, clone 483.15
相关产品
merck millipore,默克密理博,MAB16983,Anti-Integrin α4 Antibody, clone P1H4
merck millipore,默克密理博,MABE539,Anti-FOX AntibodyO4, clone EPR5442, rabbit monoclonal
merck millipore,默克密理博,ABT166,Anti-NEDD9 Antibody
merck millipore,默克密理博,05-1064,Anti-Phospho-Stat1 (Tyr701) Antibody, clone 5C9.2
merck millipore,默克密理博,MAB3560,Anti-8-Oxoguanine Antibody, clone 483.15
merck millipore,默克密理博,MABC272,Anti-Annexin VI Antibody, clone 4B11.1
merck millipore,默克密理博,GF140,Vascular Endothelial Growth Factor 165, Recombinant mouse
merck millipore,默克密理博,05-950,Anti-p54nrb/NonO Antibody, clone 78-1-C6
merck millipore,默克密理博,06-668,Anti-Rsk1/MAPKAP Kinase 1a Antibody