- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,05-950,Anti-p54nrb/NonO Antibody, clone 78-1-C6
产品名称：Anti-p54nrb/NonO Antibody, clone 78-1-C6
产品型号：05-950
Anti-p54nrb/NonO Antibody, clone 78-1-C6 is a high quality Mouse Monoclonal Antibody for the detection of p54nrb/NonO & has been validated in IP, WB & IHC.
merck millipore,默克密理博,05-950,Anti-p54nrb/NonO Antibody, clone 78-1-C6
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-950 品牌系列 Upstate
商名 - Upstate
描述 Anti-p54nrb/NonO Antibody, clone 78-1-C6 产品信息 格式 Purified 应用 应用 Anti-p54nrb/NonO Antibody, clone 78-1-C6 is a high quality Mouse Monoclonal Antibody for the detection of p54nrb/NonO & has been validated in IP, WB & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
生物信息 免疫原品种 KLH-conjugated, synthetic peptide corresponding to amino acids TVREAGPPAFYRPNS 克隆 clone 78-1-C6 宿主 Mouse 特异性 p54nrb/NonO 同种型 IgG 品种反应性 RatHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_007363
基因符号 - P54NRB
- NONO
- NRB54
- nrb
- NMT55
- p54nrb
- p54
- P54
- NRB
纯化方法 Protein G purfied UniProt编号 - Q15233
UniProt汇总 FUNCTION: SwissProt: Q15233 # DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site (By similarity). Involved in pre-mRNA splicing, probably as an heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. Nono is involved in transcriptional regulation. The SFPQ-NONO-NR5A1/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription (By similarity).
SIZE: 471 amino acids; 54232 Da
SUBUNIT: Monomer and component of the SFPQ-NONO complex, which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits. NONO is a component of spliceosome and U5.4/6 snRNP complexes. Interacts with PSPC1 and SNRPA/U1A. Part of complex consisting of SFPQ, NONO and MATR3. Part of a complex consisting of SFPQ, NONO and NR5A1/SF-1. Part of a complex consisting of SFPQ, NONO and TOP1. Interacts with SPI1 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Also found in a number of breast tumor cell lines.
PTM: The N-terminus is blocked.
DISEASE:SwissProt: Q15233 # A chromosomal aberration involving NONO may be a cause of papillary renal cell carcinoma (PRCC). Translocation t(X;X)(p11.2;q13.1) with TFE3.
SIMILARITY: SwissProt: Q15233 ## Contains 2 RRM (RNA recognition motif) domains.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,GF140,Vascular Endothelial Growth Factor 165, Recombinant mouse
下一件merck millipore产品：merck millipore,默克密理博,06-668,Anti-Rsk1/MAPKAP Kinase 1a Antibody
相关产品
merck millipore,默克密理博,05-1064,Anti-Phospho-Stat1 (Tyr701) Antibody, clone 5C9.2
merck millipore,默克密理博,324840,EGFR/ErbB-2/ErbB-4 Inhibitor - CAS 881001-19-0 - Calbiochem
merck millipore,默克密理博,MAB3560,Anti-8-Oxoguanine Antibody, clone 483.15
merck millipore,默克密理博,MABC272,Anti-Annexin VI Antibody, clone 4B11.1
merck millipore,默克密理博,GF140,Vascular Endothelial Growth Factor 165, Recombinant mouse
merck millipore,默克密理博,06-668,Anti-Rsk1/MAPKAP Kinase 1a Antibody
merck millipore,默克密理博,APT428,CaspaTag Caspase 8 In Situ Assay Kit 25, Fluorescein
merck millipore,默克密理博,382110,Histone Acetyltransferase Inhibitor II - CAS 932749-62-7 - Calbiochem
