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merck millipore,默克密理博,MAB16983,Anti-Integrin α4 Antibody, clone P1H4
产品名称：Anti-Integrin α4 Antibody, clone P1H4
产品型号：MAB16983
Anti-Integrin α4 Antibody, clone P1H4 detects level of Integrin α4 & has been published & validated for use in ELISA, FC, IP, IC, IH.
merck millipore,默克密理博,MAB16983,Anti-Integrin α4 Antibody, clone P1H4
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Pm, H IHC, ELISA, FC, ICC M Purified Monoclonal Antibody 描述 产品目录编号 MAB16983 Replaces 04-1131 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Integrin α4 Antibody, clone P1H4 Alternate Names - CD49d
产品信息 格式 Purified 演示 Purified immunoglobulin from Protein A Sepharose™ chromatography. Liquid in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.01% sodium azide. 应用 应用 Anti-Integrin α4 Antibody, clone P1H4 detects level of Integrin α4 & has been published & validated for use in ELISA, FC, IP, IC, IH. 主要应用 - Immunohistochemistry
- ELISA
- Flow Cytometry
- Immunocytochemistry
应用说明 Immunohistochemistry (preferred fixatives are acetone and alcohols)
Immunocytochemistry
Immunoprecipitation
FACS Analysis
ELISA
Radioimmunoassay
Biological Activity: MAB16983 inhibits CS-1 and VCAM binding.
Optimal working dilutions must be determined by end user.生物信息 克隆 P1H4 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The involvement of integrins in vascular proliferation, adhesion, and wound repair and have been well-documented. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Monoclonal antibody MAB16983 was produced by immunization with human T lymphocytes. The antibody is reactive with integrin a4 from primate and human species. 同种型 IgG1 品种反应性 PrimateHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_000876.3
Entrez基因汇总 The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. 基因符号 - ITGA4
- CD49D
UniProt编号 - P13612
UniProt汇总 FUNCTION: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
SIZE: 1032 amino acids; 114,900 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DOMAIN: The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
SIMILARITY: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at +2-8C. 包装信息 数量 100 µg
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