- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,FCMAB330F,Milli-Mark™ Anti-Rac1-FITC Antibody, clone 23A8
产品名称：Milli-Mark™ Anti-Rac1-FITC Antibody, clone 23A8
产品型号：FCMAB330F
Milli-Mark Anti-Rac1-FITC Antibody, clone 23A8 detects level of Rac1 & has been published & validated for use in FC.
merck millipore,默克密理博,FCMAB330F,Milli-Mark™ Anti-Rac1-FITC Antibody, clone 23A8
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, R, M FC M FITC Monoclonal Antibody 描述 产品目录编号 FCMAB330F 商名 - Milli-Mark
描述 Milli-Mark™ Anti-Rac1-FITC Antibody, clone 23A8 背景信息 Rac1 is a member of a RhoGTPase subfamily (Rac1-Rac4) that transduces extracellular signals from G-coupled protein receptors (GPCR), integrins and growth factor receptors to effector molecules that modulate multiple signaling pathways. While Rac1 supports the activation of MAPkinase pathways and gene activation, it’s most important functions include the regulation of cytoskeletal structures. Together with Rho (regulator of stress fibers) and Cdc42 (regulator of filopodia), Rac modulates the formation of focal adhesion (FA) complexes; membrane ruffles and lamellipodia that contribute to important cell functions related to cell attachment and movement. 产品信息 格式 FITC 控制 - B35 cells
演示 Purified mouse monoclonal IgG2b conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Milli-Mark Anti-Rac1-FITC Antibody, clone 23A8 detects level of Rac1 & has been published & validated for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Recombinant protein containing the full length human Rac1. 克隆 23A8 宿主 Mouse 特异性 Antibody recognizes Rac1. Slight Rac2 cross-reactivity. 同种型 IgG2b 品种反应性 HumanRatMouse Species Reactivity Note Tested and passed on Rat. Predicted to react with Mouse based on 100% sequence homology. Predicted to react with Human based on immunogen design. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_008839
基因符号 - p21-Rac1
- RAC1
- MGC111543
- ORFNames=MIG5
- PAK1
- MIG5
- TC-25
纯化方法 Protein G Purified UniProt编号 - P63000
UniProt汇总 FUNCTION: SwissProt: P63000 # Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP- dependent manner, suggesting that the insertion does not completely abolish effector interaction.
SIZE: 192 amino acids; 21450 Da
SUBUNIT: Interacts with the GEF proteins PREX1, RASGRF2, DOCK1, DOCK2 and DOCK7, which promote the exchange between GDP and GTP, and therefore activate it. Interacts with PARD6A, PARD6B and PARD6G in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ), which plays a central role in epithelial cell polarization. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Interacts with RALBP1 via its effector domain. Interacts with PLXNB1. Part of a complex with MAP2K3, MAP3K3, CCM2 and DEF6. Interacts with BAIAP2, CYFIP1/SRA-1 and DEF6. Interacts with Y.pseudotuberculosis YPKA and PLCB2.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Melanosome. Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C- terminal cysteine (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
TISSUE SPECIFICITY: Isoform B is predominantly identified in skin and epithelial tissues from the intestinal tract. The expression of isoform B is elevated in colorectal tumors at various stages of neoplastic progression, as compared to their respective adjacent tissues.
DOMAIN: SwissProt: P63000 The effector region mediates interaction with DEF6.
SIMILARITY: Belongs to the small GTPase superfamily. Rho family.产品使用声明 质量保证 Evaluated by flow cytometry using B35 cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
上一件merck millipore产品：merck millipore,默克密理博,HSCRMAG-32K,MILLIPLEX MAP Human Soluble Cytokine Receptor Panel- Immunology Multiplex Assay
下一件merck millipore产品：merck millipore,默克密理博,ECM671,QCM™ Gelatin Invadopodia Assay (Red)
相关产品
merck millipore,默克密理博,MAB399,Anti-Acetylcholine Receptor-α Antibody, Nicotinic AChR, clone D6
merck millipore,默克密理博,AB5414P,Anti-Taurine Transporter Antibody
merck millipore,默克密理博,PP65-K,Gamma Globulin Rabbit, Crude
merck millipore,默克密理博,386790,Hydrogen Peroxide - CAS 7722-84-1 - Calbiochem
merck millipore,默克密理博,ECM671,QCM™ Gelatin Invadopodia Assay (Red)
merck millipore,默克密理博,539229,Anti-Protein Disulfide Isomerase Rabbit pAb
merck millipore,默克密理博,MAB16983,Anti-Integrin α4 Antibody, clone P1H4
merck millipore,默克密理博,MABE539,Anti-FOX AntibodyO4, clone EPR5442, rabbit monoclonal