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品种反应性 主要应用 宿主 格式 抗体类型 M, H, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT166 描述 Anti-NEDD9 Antibody Alternate Names - Renal carcinoma antigen NY-REN-12 p105
- Neural precursor cell expressed developmentally down-regulated protein 9
- Cas scaffolding protein family member 2
- CRK-associated substrate-related protein
- Enhancer of filamentation 1
背景信息 Enhancer of filamentation 1, also known as CRK-associated substrate-related protein (CAS-L) or Cas scaffolding protein family member 2 or Neural precursor cell expressed developmentally down-regulated protein 9 (NEDD-9), or Renal carcinoma antigen NY-REN-12 p105, and encoded by the gene NEDD9 or CASL or CASS2, is a docking protein that plays a central role in coordinating tyrosine kinase mediated signaling for cell adhesion. NEDD9 controls the signals between focal adhesions at the cell periphery and the mitotic spindle in response to growth factors and signals. NEDD9 interacts with integrins and various other cellular proteins including BCAR3 and SH2D3C. It is localized to the cytoplasm in most cells but location can vary depending upon the cell type and function. NEDD9 is also found in cellular projections and lamellipodium and is found in the nucleus depending upon the cellular microenvironment. NEDD9 has multiple isoforms and active proteolytic fragments ranging from 55 kDa to 115 kDa. Isoforms p105 and p115 are predominantly cytoplasmic and associate with focal adhesions while p55 associates with the mitotic spindle. NEDD9 is highly expressed in most cells and tissues and is typically induced upon cell growth and down regulated in adult tissues such as brain. NEDD9 is processed during the cell cycle into multiple proteolytic fragments that appear to have important functions at specific times during the cell cycle process. In cancer NEDD9 over expression can promote tumor growth and NEDD9 acts directly to stabilize Aurora A kinase which is often over expressed in many cancers. Destabilization of Aurora A via the inhibition or destruction of NEDD9 allows for tumor reduction, thus NEDD9 expression is being examined as a potential cancer marker. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Nedd-9 using this rabbit polyclonal antibody, Anti-NEDD9 Antibody validated for use in western blotting. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human near the C-terminus of NEDD9. 表位 Near C-terminus 宿主 Rabbit 品种反应性 MouseHumanRat Species Reactivity Note Human, Rat, Mouse. Predicted to react with Bovine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_006394
基因符号 - CASS2
- NEDD9
- CASL
纯化方法 Affinity purified UniProt编号 - Q14511
产品使用声明 质量保证 Evaluated by Western Blotting in HUVEC cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected NEDD9 in 10 µg of HUVEC cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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