merck millipore,默克密理愽
  • merck millipore,默克密理博,05-363,Anti-Cyclin E Antibody, clone HE12

  • merck millipore,默克密理博,05-363,Anti-Cyclin E Antibody, clone HE12

    产品名称：Anti-Cyclin E Antibody, clone HE12
    产品型号：05-363
    Anti-Cyclin E Antibody, clone HE12 is a high quality Mouse Monoclonal Antibody for the detection of Cyclin E & has been validated in IP, WB, ICC.

    merck millipore,默克密理博,05-363,Anti-Cyclin E Antibody, clone HE12

  • 产品介绍
  • merck millipore,默克密理博,05-363,Anti-Cyclin E Antibody, clone HE12

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 05-363
    Replaces 04-223
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-Cyclin E Antibody, clone HE12
    背景信息 Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
    产品信息
    格式 Purified
    控制
    • A431 cell lysate
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide
    应用
    应用 Anti-Cyclin E Antibody, clone HE12 is a high quality Mouse Monoclonal Antibody for the detection of Cyclin E & has been validated in IP, WB, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    生物信息
    免疫原品种 Recombinant human cyclin E
    克隆 clone HE12
    宿主 Mouse
    特异性 human p52cyclin E
    同种型 IgG
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_001238, NM_057182
    Entrez基因汇总 The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
    基因符号
    • CCNE
    • CCNE1
    纯化方法 Protein G chromatography
    UniProt编号
    • P24864
    UniProt汇总 FUNCTION: SwissProt: P24864 # Essential for the control of the cell cycle at the G1/S (start) transition.
    SIZE: 410 amino acids; 47077 Da
    SUBUNIT: Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1.
    SUBCELLULAR LOCATION: Nucleus.
    TISSUE SPECIFICITY: Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
    PTM: Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.
    SIMILARITY: SwissProt: P24864 ## Belongs to the cyclin family. Cyclin E subfamily.
    产品使用声明
    质量保证 routinely evaluated in immunoblot on human A431 lysate
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C or 6 months at 4°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,05-363,Anti-Cyclin E Antibody, clone HE12

上一件merck millipore产品：merck millipore,默克密理博,539482,PKA, His•Tag, Active, Human, Recombinant, E. coli
下一件merck millipore产品：merck millipore,默克密理博,07-1286,Anti-ATM Antibody


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