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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB4331 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-MELK Antibody, clone 6C1.3 Alternate Names - Maternal Embryonic Leucine Zipper Kinase
背景信息 Melk, (Maternal Embryonic Leucine Zipper Kinase) is a serine-threonine kinase of the snfI/AMPK family that is expressed in developing neuroepithelium, self-renewing neural stem cells and granule cell precursors. It is also considered an important brain tumor marker, being highly expressed in gliobastoma, astrocytomas, and medulablastomas. 产品信息 格式 Purified 演示 Purified ascites. Liquid in PBS, pH 7.0. Contains 0.1% sodium azide. 应用 应用 This Anti-MELK Antibody, clone 6C1.3 is validated for use in WB for the detection of MELK. 主要应用 - Western Blotting
应用说明 Western blot: Recommended dilution: 1:500 (2 μg/mL)
Expected Molecular Weight: 74.5 kDa
Note: Bands may be present at a higher molecular weight due to glycosolation.生物信息 免疫原品种 MELK Recombinant protein. 克隆 6C1.3 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2κ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_014791.2
基因符号 - EC 2.7.11.1
- MELK
- hMELK
- HPK38
- KIAA0175
- hPK38
- OTTHUMP00000046113
UniProt编号 - Q14680
UniProt汇总 FUNCTION: SwissProt: Q14680 # Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis.
SIZE: 651 amino acids; 74642 Da
SUBUNIT: Interacts with ZNF622 and PPP1R8.
SUBCELLULAR LOCATION: Cytoplasm (Potential).
TISSUE SPECIFICITY: Expressed in placenta, kidney, thymus, testis, ovary and intestine.
PTM: Autophosphorylated. Thr-478 phosphorylation during mitosis promotes interaction with PPP1R8 (Probable).
SIMILARITY: SwissProt: Q14680 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. & Contains 1 KA1 (kinase-associated) domain. & Contains 1 protein kinase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at 2-8 °C from date of shipment 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,14-253,p38β2/SAPK2b2 Protein, active, 10 µg
下一件merck millipore产品：merck millipore,默克密理博,539482,PKA, His•Tag, Active, Human, Recombinant, E. coli
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