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merck millipore,默克密理博,440202,LY 294002 - CAS 154447-36-6 - Calbiochem
产品名称：LY 294002 - CAS 154447-36-6 - Calbiochem
产品型号：440202
A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC₅₀ = 1.4 µM) that acts on the ATP-binding site of the enzyme.
merck millipore,默克密理博,440202,LY 294002 - CAS 154447-36-6 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₉H₁₇NO₃ 154447-36-6 描述 概述 A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC50 = 1.4 µM) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50 µM. Promotes the nuclear accumulation of active GSK-3b. Reported to suppress the proliferation of murine embryonic stem cells. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. Shown to bind to the same site as I-BET (Cat. No. 40101050 ~ 10 µM). A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440204) in DMSO is also available. 产品目录编号 440202 品牌系列 Calbiochem®
同义词 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV 参考 参考 Dittman, A., et al. 2013. ACS Chem. Biol. 9, 495.
Bechard, M., and Dalton. S. 2009. Mol. Cell. Biol. 29, 2092.
Lianguzova, M.S. et al. 2007. Cell Biol. Int. 31, 330.
Baumann, P., and West, S.C. 1998. Proc. Natl. Acad. Sci. USA 95, 14066.
Cardone, M.H., et al. 1998. Science 282, 1318.
Vlahos, C.J., et al. 1995. J. Immunol. 154, 2413.
Yano, H., et al. 1995. Biochem. J. 312, 145.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
Selected Citations
Lee, J., et al. 2009. Cell Stem Cell 5, 76.
产品信息 CAS号 154447-36-6 具有ATP竞争性 Y 形式 Off-white solid Hill配方 C₁₉H₁₇NO₃ 化学配方 C₁₉H₁₇NO₃ Molar Mass 307.4 可逆 Y 结构配方图像 生物信息 主靶 Phosphatidylinositol 3-kinase 主靶IC50 1.4 µM against phosphatidylinositol 3-kinase 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
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