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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB, ICC M Culture Supernatant Monoclonal Antibody 描述 产品目录编号 MAB4140 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-MDR3 Antibody, clone P3 II-26 产品信息 格式 Culture Supernatant 演示 Liquid containing 0.7% BSA and 0.1% sodium azide. 应用 应用 Anti-MDR3 Antibody, clone P3 II-26 is an antibody against MDR3 for use in WB, IC, IH. 主要应用 - Immunohistochemistry
- Western Blotting
- Immunocytochemistry
不建议的应用 - Immunohistochemistry (Paraffin)
应用说明 Western Blotting: MDR3 is a 140 kDa protein.
Immunocytochemistry: 1:20 - 1:50 on acetone-fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone-fixed frozen sections
Not suitable for paraffin-embedded tissues
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Mab was selected after immunization with a fusion protein consisting of Gluthatione-S-Transferase and a fragment of MDR3 P-gp comprising aa 629-692. 克隆 P3 II-26 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody reacts with an internal epitope of MDR3 P-gp. It does not cross-react with the human MDR1 P-gp. It has been reported that this clone also cross reacts with mouse MDR2 Pgp {Kok et al 2003 {}. 同种型 IgG2b 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_018850.2
- NM_000443.3
- NM_018849.2
Entrez基因汇总 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. 基因符号 - EC 3.6.3.44
- ABCB4
- PGY3
- PFIC3
- PFIC-3
- MDR2/3
- MDR3
- MDR2
- ABC21
- GBD1
UniProt编号 - P21439
UniProt汇总 FUNCTION: SwissProt: P21439 # Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Human MDR3 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.
SIZE: 1286 amino acids; 141523 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
DISEASE: SwissProt: P21439 # Defects in ABCB4 are the cause of progressive familial intrahepatic cholestasis type III (PFIC3) [MIM:602347]. PFIC3 is an autosomal recessive liver disorder presenting with early onset cholestasis that progresses to cirrhosis and liver failure before adulthood. It is characterized by elevated serum gamma- glutamyltransferase levels. & Defects in ABCB4 are the cause of intrahepatic cholestasis of pregnancy (ICP) [MIM:147480]; also known as obstetric cholestasis. ICP is a liver disorder of pregnancy with serious consequences for the mother and fetus. Cholestasis results from abnormal biliary transport from the liver into the small intestine, and ICP is characterized by the occurrence of cholestasis in pregnancy in women with an otherwise normal medical history. The classical maternal feature is generalized pruritus, becoming more severe with advancing gestation. ICP causes fetal distress, spontaneous premature delivery and unexplained third trimester intrauterine death. & Defects in ABCB4 are a cause of cholelithiasis [MIM:600803]; also known as gallstones.
SIMILARITY: SwissProt: P21439 ## Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. 包装信息 数量 100 µg
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