merck millipore,默克密理愽
  • merck millipore,默克密理博,557352,RORα/γ Agonist, SR1078 - Calbiochem

  • merck millipore,默克密理博,557352,RORα/γ Agonist, SR1078 - Calbiochem

    产品名称：RORα/γ Agonist, SR1078 - Calbiochem
    产品型号：557352
    The RORα/γ Agonist, SR1078 controls the biological activity of RORα/γ. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,557352,RORα/γ Agonist, SR1078 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,557352,RORα/γ Agonist, SR1078 - Calbiochem

    重要规格表

    经验配方
    C₁₇H₁₀F₉NO₂
    描述
    概述 A cell-permeable diaryl amide derived from T1317 (a known LXR agonist and retinoic acid receptor (ROR) inverse agonist) that acts as a highly selective agonist of RORα/γ and does not exhibit affinity for FXR, LXRa and LXRb. Shown to stabilize p53 in cancer cells and increase the expression of p21 and PUMA. Induces apoptosis in hepatocellular carcinoma (HepG2) cells in a RORα and p53-dependent process. Also reported to increase the expression of Sox4 and REV-ERBα in HepG2 cells. Exhibits suitable pharmacokinetic properties with sustained plasma levels even after 8 hours following a single i.p. injection. Exposure to SR1078 Induces expression of glucose-6-phosphatase and fibroblast growth factor 21 in murine models (10 mg/kg/i.p).
    产品目录编号 557352
    品牌系列 Calbiochem®
    同义词 N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide, SR1078
    参考
    参考 Wang, Y., et al. 2010. ACS Chem Biol. 5, 1029.PLoS One.7, e34921.
    产品信息
    形式 White solid
    Hill配方 C₁₇H₁₀F₉NO₂
    Molar Mass 431.25
    可逆 Y
    结构配方图像
    生物信息
    主靶 RORα/γ
    纯度 ≥99% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Blue Ice Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,557352,RORα/γ Agonist, SR1078 - Calbiochem

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