merck millipore,默克密理愽
  • merck millipore,默克密理博,14-253,p38β2/SAPK2b2 Protein, active, 10 µg

  • merck millipore,默克密理博,14-253,p38β2/SAPK2b2 Protein, active, 10 µg

    产品名称：p38β2/SAPK2b2 Protein, active, 10 µg
    产品型号：14-253
    Active, N-terminal GST fusion protein corresponding to full length human p38β2/SAPK2b2 activated with MKK6. For use in Kinase Assays.

    merck millipore,默克密理博,14-253,p38β2/SAPK2b2 Protein, active, 10 µg

  • 产品介绍
  • merck millipore,默克密理博,14-253,p38β2/SAPK2b2 Protein, active, 10 µg

    描述
    产品目录编号 14-253
    品牌系列 Upstate
    商名
    • Upstate
    描述 p38β2/SAPK2b2 Protein, active, 10 µg
    概述 N-terminal GST fusion protein corresponding to full length human p38β2/SAPK2b2 activated with MKK6.
    应用
    应用 Active, N-terminal GST fusion protein corresponding to full length human p38β2/SAPK2b2 activated with MKK6. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 full length human p38β2/SAPK2b2, expressed in E. coli.
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_002751.5
    Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
    基因符号
    • p38beta2
    • MAPK11
    • p38-2
    • SAPK2B
    • SAPK2
    • PRKM11
    • P38BETA2
    • P38B
    • p38b
    • p38Beta
    蛋白靶 p38β2/SAPK2b2
    纯化方法 Affinity chromatography on glutathione-agarose beads
    靶子系列 CMGC
    UniProt编号
    • Q15759
    UniProt汇总 FUNCTION: SwissProt: Q15759 # Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2.
    COFACTOR: Magnesium (By similarity).
    SIZE: 364 amino acids; 41357 Da
    TISSUE SPECIFICITY: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
    DOMAIN:SwissProt: Q15759 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
    PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme (Probable).
    SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of myelin basic protein
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -20°C
    包装信息
    数量 10 µg

    merck millipore,默克密理博,14-253,p38β2/SAPK2b2 Protein, active, 10 µg

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