merck millipore,默克密理愽
  • merck millipore,默克密理博,401011,Hypothemycin - CAS 76958-67-3 - Calbiochem

  • merck millipore,默克密理博,401011,Hypothemycin - CAS 76958-67-3 - Calbiochem

    产品名称：Hypothemycin - CAS 76958-67-3 - Calbiochem
    产品型号：401011
    A cell-permeable cis-enone resorlic acid lactone (RAL) and (5Z)-7-Oxozeaenol analog that inhibits several kinases via an initial affinity binding to the ATP pocket.

    merck millipore,默克密理博,401011,Hypothemycin - CAS 76958-67-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,401011,Hypothemycin - CAS 76958-67-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₂₂O₈76958-67-3
    描述
    概述 A cell-permeable cis-enone resorlic acid lactone (RAL) and (5Z)-7-Oxozeaenol (Cat. No. 499610) analog that inhibits several kinases via an initial affinity binding to the ATP pocket, followed by a covalent adduct formation with a conserved ATP site cysteine residue of the targeted enzymes, including, but not limited to, Flt1/VEGFR-1, Flt3, cKit(D816V), MAPK1, MAPK2, MEK1, MKK6, PKCμ, PKD2, PRAK, and Tak1 (≥90% inhibition at 2 µM). Hypothemycin is also reported to inhibit two non-RAL targets (99% and 82% inhibition of TrkA and TrkB, respectively, at 2 µM), while one of the 46 putative cis-enone RALs targets, namely GSK-3α, is shown not to be affected. Hypothemycin inhibits multiple kinases involved in MAP kinase pathways and is therefore particularly effective in inhibiting BRAF(V600E)-dependent tumor growth. (5Z)-Zeaenol (Cat. No. 499609) may serve as a negative control.
    产品目录编号 401011
    品牌系列 Calbiochem®
    同义词 NSC 354462
    参考
    参考 Schirmer, A., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 4234.
    Solit, D.B., et al. 2006. Nature 439, 358.
    Tanaka, H., et al. 1999. Jpn. J. Cancer Res. 90, 1139.
    产品信息
    CAS号 76958-67-3
    形式 Lyophilized solid
    Hill配方 C₁₉H₂₂O₈
    化学配方 C₁₉H₂₂O₈
    Molar Mass 378.4
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,401011,Hypothemycin - CAS 76958-67-3 - Calbiochem

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