- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,04-1507,Anti-CD265/RANK Antibody, clone R12-31
产品名称：Anti-CD265/RANK Antibody, clone R12-31
产品型号：04-1507
Anti-CD265/RANK Antibody, clone R12-31 detects level of CD265/RANK & has been published & validated for use in FC.
merck millipore,默克密理博,04-1507,Anti-CD265/RANK Antibody, clone R12-31
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M FC R Purified Monoclonal Antibody 描述 产品目录编号 04-1507 描述 Anti-CD265/RANK Antibody, clone R12-31 Alternate Names - tumor necrosis factor receptor superfamily, member 11a,<br />activator of NFKB
- CD265 antigen
- Osteoclast differentiation factor receptor
- Receptor activator of NF-KB
- loss of heterozygosity, 18, chromosomal region 1
- receptor activator of nuclear factor-kappa B
- tumor necrosis factor receptor superfamily, member 11a
- tumor necrosis factor receptor superfamily, member 11a, NFKB activator
背景信息 CD265 or RANK (Receptor Activator of Nuclear Factor κ B, also known as Tumor Necrosis Factor Receptor Superfamily, member 11a or TRANCE Receptor) is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK interacts with various TRAF family proteins and induces the activation of NF-kappa B and MAPK8/JNK. RANK is also expressed on dendritic cells and facilitates immune signaling. 产品信息 格式 Purified 控制 - RAW264 macrophage cells
演示 Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 Anti-CD265/RANK Antibody, clone R12-31 detects level of CD265/RANK & has been published & validated for use in FC. 主要应用 - Flow Cytometry
应用说明 Flow Cytometry Analysis: 5 µg from a previous lot detected CD265/RANK in RAW264 macrophage cells. 生物信息 免疫原品种 Mouse CD265/RANK-transfected 2PK3 cells. 表位 Unknown 克隆 R12-31 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 特异性 This antibody recognizes CD265/RANK. 同种型 IgG2aκ 品种反应性 Mouse Species Reactivity Note Proven to react with mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_033425.3
Entrez基因汇总 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells. [provided by RefSeq] 基因符号 - TRANCER
- TNFRSF11A
- RANK
- OFE
- ODFR
- CD265
纯化方法 Protein G purfied UniProt编号 - O35305
UniProt汇总 FUNCTION: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
SUBUNIT STRUCTURE: Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6 By similarity.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential.
TISSUE SPECIFICTY: Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow.
SEQUENCE SIMILARITIES: Contains 4 TNFR-Cys repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,FCCS025106,FlowCellect™ MAPK Activation Dual Detection Kit
下一件merck millipore产品：merck millipore,默克密理博,658552,AG 1478 - CAS 175178-82-2 - Calbiochem
相关产品
merck millipore,默克密理博,492002,NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem
merck millipore,默克密理博,ABT304,Anti-TAGLN Antibody
merck millipore,默克密理博,ABE43,Anti-Ebp1 NT Antibody
merck millipore,默克密理博,FCCS025106,FlowCellect™ MAPK Activation Dual Detection Kit
merck millipore,默克密理博,658552,AG 1478 - CAS 175178-82-2 - Calbiochem
merck millipore,默克密理博,ABC245,Anti-REDD1 Antibody
merck millipore,默克密理博,05-1526,Anti-Importin subunit alpha-1 Antibody, clone 8G5
merck millipore,默克密理博,FCCH100105,FlowCellect MitoPotential Red Kit
merck millipore,默克密理博,565772,γ-Secretase Inhibitor XI - CAS 62252-26-0 - Calbiochem