merck millipore,默克密理博,658552,AG 1478 - CAS 175178-82-2

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merck millipore,默克密理博,658552,AG 1478 - CAS 175178-82-2 - Calbiochem
产品名称：AG 1478 - CAS 175178-82-2 - Calbiochem
产品型号：658552
A cell-permeable, reversible, ATP-competitive, highly potent and selective inhibitor of epidermal growth factor receptor kinase versus HER2-neu and platelet-derived growth factor receptor kinase.

merck millipore,默克密理博,658552,AG 1478 - CAS 175178-82-2 - Calbiochem

产品介绍

merck millipore,默克密理博,658552,AG 1478 - CAS 175178-82-2 - Calbiochem

重要规格表

经验配方	CAS号
C₁₆H₁₄ClN₃O₂	175178-82-2

描述
概述	A cell-permeable, reversible, ATP-competitive, highly potent and selective inhibitor of epidermal growth factor receptor kinase (IC₅₀ = 3 nM) versus HER2-neu (IC₅₀ >100 µM) and platelet-derived growth factor receptor kinase (IC₅₀ >100 µM). Abolishes MAP kinase (ERK) activation induced by Angiotensin II (Cat. No. 05-23-0101). Also inhibits the activation of EGFR kinase and MAP kinase by 4-hydroxynonenal. Downregulates ARF1 activity and disperses Golgi structure. A 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658548) in DMSO is also available.
产品目录编号	658552
品牌系列	Calbiochem®
同义词	4-(3-Chloroanilino)-6,7-dimethoxyquinazoline

参考
参考	Pan, H., et al. 2008. J. Biol. Chem. 283, In press. Liu, W., et al. 1999. J. Cell Sci. 112, 2409. Eguchi, S., et al. 1998. J. Biol. Chem. 273, 8890. Levitzki, A., and Gazit, A. 1995. Science 267, 1782. Fry, D.W., et al. 1994. Science 265, 1093. Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047. Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.

参考

Pan, H., et al. 2008. J. Biol. Chem. 283, In press.
Liu, W., et al. 1999. J. Cell Sci. 112, 2409.
Eguchi, S., et al. 1998. J. Biol. Chem. 273, 8890.
Levitzki, A., and Gazit, A. 1995. Science 267, 1782.
Fry, D.W., et al. 1994. Science 265, 1093.
Osherov, N., and Levitski, A. 1994. Eur. J. Biochem. 225, 1047.
Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.

产品信息
CAS号	175178-82-2
具有ATP竞争性	Y
声明	Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
形式	Pale yellow solid
Hill配方	C₁₆H₁₄ClN₃O₂
化学配方	C₁₆H₁₄ClN₃O₂
Molar Mass	315.8
可逆	Y
结构配方图像

生物信息
主靶	Epidermal growth factor receptor kinase
主靶IC₅₀	3 nM against epidermal growth factor receptor kinase
纯度	≥98% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.