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merck millipore,默克密理博,ABE43,Anti-Ebp1 NT Antibody
产品名称：Anti-Ebp1 NT Antibody
产品型号：ABE43
Anti-Ebp1 N-terminal Antibody is a Rabbit Polyclonal Antibody for detection of Ebp1 also known as Proliferation-associated protein 2G4 & has been validated in WB, ICC.
merck millipore,默克密理博,ABE43,Anti-Ebp1 NT Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H, M ICC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 ABE43 Replaces 07-397 描述 Anti-Ebp1 NT Antibody Alternate Names - ErbB3-binding protein Ebp1
- Proliferation-associated protein 2G4
- Cell cycle protein p38-2G4 homolog
- hG4-1
- ErbB3-binding protein 1
- ErbB-3 binding protein 1
背景信息 Ebp1 is an RNA-binding protein involved in growth regulation. In cancer cells, this protein and has been implicated in growth inhibition and differentiation. Ebp1 is known to bind ribosomal and double-stranded RNA. It is a found in pre-ribosomal ribonucleoprotein complexes and is believed to play a role in ribosome assembly and rRNA processing. This protein is also a component of cytoplasmic bcl-2 messenger ribonucleoprotein. Through interactions with histion deacetylases, this protein can act transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes. Ebp1 also interacts with the cytoplasmic domain of the ErbB3 receptor, potentially transducing regulatory growth signals. 产品信息 格式 Serum 控制 - A431 Cell Lysate.
演示 Rabbit Polyclonal Serum with 0.05% sodium azide 应用 应用 Anti-Ebp1 N-terminal Antibody is a Rabbit Polyclonal Antibody for detection of Ebp1 also known as Proliferation-associated protein 2G4 & has been validated in WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry:
A 1:500 dilution from a representative lot detected Ebp1 in NIH/3T3, A431, and HeLa cells.生物信息 免疫原品种 Linear Peptide corresponding to the N-terminus of Ebp1. 表位 N-terminus 宿主 Rabbit 特异性 Recognizes Ebp-1. 同种型 IgG 品种反应性 RatHumanMouse Species Reactivity Note Tested and passed on Human, Mouse, and Rat. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_006182
Entrez基因汇总 This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq] 基因符号 - PA2G4
- EBP1
- HG4-1
- p38-2G4
纯化方法 Unpurified UniProt编号 - Q9UQ80
UniProt汇总 Function: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) By similarity. Ref.8 Ref.10 Ref.11 Ref.12
Subunit structure: Interacts with the cytoplasmic domain of non-phosphorylated ERBB3; the interaction requires PKC activity. Interacts with AR. Treatment with HRG leads to dissociation from ERBB3 and increases association with AR. Interacts with NCL/nucleolin. Component of a ribonucleoprotein complex containing at least PA2G4, NCL, TOP1, PABPC2, RPLP0, acetylated histone H1 (HIST1H1A or H1F1), histone H1 2/4, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21, RPL11, RPL12, RPL28, RPL27, RPLP2 and RPL24. Interacts with HDAC2. Interacts with RB1; the interaction is enhanced upon PA2G4 dephosphorylation. Ref.8 Ref.10 Ref.12 Ref.2 Ref.7 Ref.19
Subcellular location: Cytoplasm. Nucleus › nucleolus. Note: Tranlocates to the nucleus upon treatment with HRG. Ref.11 Ref.2 Ref.9
Tissue specificity: Expressed in several cell lines tested, including primary and transformed cell lines. Ref.11
Post-translational modification: Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent. Ref.7 Ref.13 Ref.14 Ref.15 Ref.17 Ref.18
Miscellaneous: Does not contain metal cofactors and does not have aminopeptidase activity.
Sequence similarities: Belongs to the peptidase M24 family.
产品使用声明 质量保证 Evaluated by Western Blotting in A431 cell lysate. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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