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merck millipore,默克密理博,492002,NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem
产品名称：NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem
产品型号：492002
The NOX1 Inhibitor, ML171, also referenced under CAS 6631-94-3, controls the biological activity of NOX1.
merck millipore,默克密理博,492002,NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₄H₁₁NOS 6631-94-3 描述 概述 A highly selective, cell-permeable, and reversible 2-acetylphenothiazine that is shown to inhibit NADPH Oxidase-1 (Nox1) (IC50 = 0.129 µM, and 0.25 µM) in human HT29 and HEK293 cell-based assays, respectively. Unlike most other currently used Nox inhibitors, it only has marginal activity on other cellular ROS-producing enzymes and receptors including the other Nox isoforms (IC50 = 5 µM, 3 µM and 5 µM for Nox2, Nox3, and Nox4, respectively) and xanthine oxidase, XO, (IC50 = 5.5 µM) in HEK293 cell-based assays. It is also shown to block Nox1-dependent ROS generation in HEK293 cultures dose-dependently at concentrations up to ~ 100 nM; however, its inhibitory effect is reversed through over-expression of Nox1, thereby suggesting that this compound is highly selective for Nox1, with little effect against Nox2-dependent ROS generation (IC50 > 10 µM). Qualitatively, it displays an inhibitory effect against SrcYF-induced ECM-degrading invadopodia formation in DLD1 Human Colon Cancer Cells. 产品目录编号 492002 品牌系列 Calbiochem®
同义词 NADPH Oxidase-1 Inhibitor, ML171, 2-APT, 2-acetylphenothiazine 参考 参考 Gianni, D., et al. 2010. ACS Chem. Biol. 5, 981. 产品信息 CAS号 6631-94-3 形式 Dark yellow-orange powder Hill配方 C₁₄H₁₁NOS 化学配方 C₁₄H₁₁NOS Molar Mass 241.31 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Regulatory Review
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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