- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,565772,γ-Secretase Inhibitor XI - CAS 62252-26-0 - Calbiochem
产品名称：γ-Secretase Inhibitor XI - CAS 62252-26-0 - Calbiochem
产品型号：565772
The γ-Secretase Inhibitor XI, also referenced under CAS 62252-26-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
merck millipore,默克密理博,565772,γ-Secretase Inhibitor XI - CAS 62252-26-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₀H₈ClNO₃ 62252-26-0 描述 概述 A cell-permeable, active site directed, irreversible serine protease inhibitor that belongs to the class of isocoumarin analogs. Acts as a potent and selective inhibitor of γ-secretase and blocks the production of both amyloid-β40 (Aβ40) and Aβ42 (IC50 < 100 µM) in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP). Note: t1/2 = 200 min in 100 µM HEPES, 500 µM NaCl, and 10% DMSO, pH 7.5. 产品目录编号 565772 品牌系列 Calbiochem®
同义词 7-Amino-4-chloro-3-methoxyisocoumarin, JLK6 参考 参考 Esler, W.P., et al. 2002. Nat. Cell Biol. 4, E110.
Petit, A., et al. 2002. Nat. Cell Biol. 4, E111.
Petit, A., et al. 2001. Nat. Cell Biol. 3, 507.
Kerrigan, J.E., et al. 1995. J. Med. Chem. 38, 544.
Harper, J.W. and Powers, J.C. 1985. Biochemistry 24, 7200.产品信息 CAS号 62252-26-0 具有ATP竞争性 N 形式 Yellow solid Hill配方 C₁₀H₈ClNO₃ 化学配方 C₁₀H₈ClNO₃ Molar Mass 225.6 可逆 N 结构配方图像 生物信息 主靶 γ-secretase and blocks the production of both Aβ₄₀ and Aβ₄₂ in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP) 主靶IC50 < 100 µM against γ-secretase and blocks the production of both amyloid-β40 (Aβ40) and Aβ42 in HEK293 cells expressing wild-type and Swedish-mutant β-amyloid precursor protein (APP) 纯度 ≥97% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. This product is not stable in aqueous solution, hence, dilute in aqueous solution right prior to use (t½ at 25°C = 3.3 h in 100 mM HEPES, 500 mM NaCl, pH 7.5, with 10% DMSO). 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,FCCH100105,FlowCellect MitoPotential Red Kit
下一件merck millipore产品：merck millipore,默克密理博,ISEQ15150,Immobilon-PSQ 方片膜，PVDF，0.2 µm，15 x 15 cm
相关产品
merck millipore,默克密理博,04-1507,Anti-CD265/RANK Antibody, clone R12-31
merck millipore,默克密理博,658552,AG 1478 - CAS 175178-82-2 - Calbiochem
merck millipore,默克密理博,ABC245,Anti-REDD1 Antibody
merck millipore,默克密理博,05-1526,Anti-Importin subunit alpha-1 Antibody, clone 8G5
merck millipore,默克密理博,FCCH100105,FlowCellect MitoPotential Red Kit
merck millipore,默克密理博,ISEQ15150,Immobilon-PSQ 方片膜，PVDF，0.2 µm，15 x 15 cm
merck millipore,默克密理博,3810-OP,OmniPur DTE - CAS 6892-68-8 - Calbiochem
merck millipore,默克密理博,14-527M,Ros Protein, active, 250 µg
merck millipore,默克密理博,AB3768,Anti-Rad54L Antibody
merck millipore,默克密理博,AP182SA6,Donkey Anti-Rabbit IgG Antibody, Cy5 Conjugated