merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE65,Anti-Tristetraprolin Antibody (TTP), clone 1-3

  • merck millipore,默克密理博,MABE65,Anti-Tristetraprolin Antibody (TTP), clone 1-3

    产品名称：Anti-Tristetraprolin Antibody (TTP), clone 1-3
    产品型号：MABE65
    This Tristetraprolin antibody is validated for use in WB for the detection of the Tristetraprolin protein.

    merck millipore,默克密理博,MABE65,Anti-Tristetraprolin Antibody (TTP), clone 1-3

  • 产品介绍
  • merck millipore,默克密理博,MABE65,Anti-Tristetraprolin Antibody (TTP), clone 1-3

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBMProtein A PurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE65
    描述 Anti-Tristetraprolin Antibody (TTP), clone 1-3
    Alternate Names
    • Protein TIS11A
    • zinc finger protein 36, C3H type, homolog (mouse)
    • Growth factor-inducible nuclear protein NUP475
    • Zinc finger protein 36 homolog
    • G0/G1 switch regulatory protein 24
    • zinc finger protein, C3H type, 36 homolog (mouse)
    • zinc finger protein, C3H type, 36 homolog
    背景信息 TTP (Tristetraprolin, Nup 475, TIS11, G0S24, or ZFP36) is a member of the CCCH tandem zinc finger protein family. It is a nuclear RNA-binding protein that functions as a trans-acting factor. It is involved in post-transcriptional regulation of cytokine genes, most notably Tumor Necrosis Factor alpha (TNF-α). Upon activation by lipopolysaccharides, TTP binds TNF-α mRNA at AU-rich domains in the 3'-untranslated Region (3'-UTR) and induces deadenylation, thereby destabilizing the mRNA and tagging it for degradation. To produce this effect, TTP recruits other trans-acting factors to its C-terminal domain and mRNA-decay enzymes to its N-terminal domain. TTP is deactivated by phosphorylation driven by mitogen-activated protein kinase-activated protein kinase 2 (MK2) and p53. Therefore, TTP/MK2 regulates the biosynthesis of TNF-α and mediates inflammatory responses involving TNF-α. Knockout of TTP in mice produces arthritis, alopecia, dermatitis, among a range of other phenotypes related to overexpression of TNF-α.
    产品信息
    格式 Protein A Purified
    控制
    • Human thymus tissue lysate
    演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Tristetraprolin antibody is validated for use in WB for the detection of the Tristetraprolin protein.
    主要应用
    • Western Blotting
    应用说明 Western Blotting Analysis: A representative lot detected Tristetraprolin (TTP) in human lymph node and small intestine tissue.
    生物信息
    免疫原品种 Recombinant protein corresponding to the human Tristetraprolin (TTP).
    克隆 hTTP-214
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_003398
    基因符号
    • Zfp-36
    • TTP
    • G0S24
    • RNF162A
    • TIS11
    • NUP475
    • zfp-36
    • GOS24
    • TIS11A
    • tristetraprolin
    纯化方法 Protein A purified
    UniProt编号
    • P26651
    UniProt汇总 FUNCTION: mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).
    SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.
    INDUCTION: By stimulation with various mitogens.
    PTM: Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen stimulation.
    SEQUENCE SIMILARITIES: Contains 2 C3H1-type zinc fingers.
    产品使用声明
    质量保证 Evaluated by Western Blotting in human thymus tissue lysate.
    Western Blotting Analysis: A 1:2,000 dilution of this antibody detected Tristetraprolin (TTP) in 10 µg of human thymus tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE65,Anti-Tristetraprolin Antibody (TTP), clone 1-3

上一件merck millipore产品：merck millipore,默克密理博,AB9730,Anti-14-3-3 β Antibody
下一件merck millipore产品：merck millipore,默克密理博,MAB1910,Anti-Collagen Type IV α 2 Chain Antibody, clone 23IIC3


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