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品种反应性 主要应用 宿主 格式 抗体类型 Chp, H, M, Mk WB, FC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 06-1074 描述 Anti-Interleukin 21 (IL-21) Antibody Alternate Names - Interleukin-21
- Za11
- IL-21
- IL21
背景信息 Interleukin 21 (IL-21) is a cytokine that has immunoregulatory activity on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. IL-21 induces cell division/proliferation in its target cells and is expressed in activated human CD4+ T cells. IL-21 may promote the transition between innate and adaptive immunity and may play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. IL-21 expression is up-regulated in Th2 and Th17 subsets of T helper cells, as well as follicular T cells. Furthermore IL-21 is expressed in NK T cells regulating the function of these cells. IL-21 is also produced by Hodgkin's lymphoma (HL) cancer cells and may explain a great deal of the behavior of classical Hodgkin's lymphoma including clusters of other immune cells gathered around HL cells in cultures. 产品信息 格式 Affinity Purified 控制 - K562 cell lysate
演示 Purified rabbit polyclonal in PBS with 0.06% sodium azide. 应用 应用 Anti-Interleukin 21 (IL-21) Antibody is an antibody against Interleukin 21 (IL-21) for use in FC, IH(P) & WB. 主要应用 - Western Blotting
- Flow Cytometry
应用说明 Flow Cytometry Analysis: 5 µg from a previous lot detected IL-21 in human PBMC's.
Immunohistochemistry Analysis: A 1:100 dilution from a previous lot detected IL-21 in mouse spleen tissue.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human IL-21. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the C-terminus of IL-21. 品种反应性 ChimpanzeeHumanMouseMonkey Species Reactivity Note Demonstrated to react with human and mouse.
Predicted to react with monkey and chimpanzee based on 100% sequence homology.
Cow, canine, equine, and porcine (93% sequence homology). Rat (86% sequence homology).抗体类型 Polyclonal Antibody Entrez基因编号 - NP_068575
基因符号 - IL-21
- IL21
纯化方法 Affinity Purfied UniProt编号 - Q9HBE4
UniProt汇总 FUNCTION: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells By similarity. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
SUBCELLULAR LOCATION: Secreted
TISSUE SPECIFICTY: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.
SEQUENCE SIMILARITIES: Belongs to the IL-15/IL-21 family.产品使用声明 质量保证 Evaluated by Western Blot in K562 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected IL-21 on 10 µg of K562 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,16-220,Anti-phospho-Ser/Thr-Pro MPM-2 Antibody, Cy5 conjugate
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