merck millipore,默克密理博,ABS234,Anti-PI3 Kinase Antibody, p85

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Merck Millipore 默克密理愽

Replacement Information

品种反应性	主要应用	宿主	格式	抗体类型
R, H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABS234
Replaces	06-497
描述	Anti-PI3 Kinase Antibody, p85
Alternate Names	PtdIns-3-kinase regulatory subunit p85-alpha Phosphatidylinositol 3-kinase regulatory subunit alpha PI3-kinase regulatory subunit alpha PI3K regulatory subunit alpha PtdIns-3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha PI3-kinase subunit p85-alpha
背景信息	Phosphatidylinositol 3-Kinase (PI3 Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β,γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibited by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway.

参考

产品信息
格式	Affinity Purified
控制	Jurkat cell lysate
演示	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Detect PI3 Kinase, p85 using this rabbit polyclonal antibody, Anti-PI3 Kinase Antibody, p85 validated for use in western blotting & IP.
主要应用	Western Blotting
应用说明	Immunoprecipitation Analysis: A representative lot immunoprecipitated PI3 Kinase, p85 in 0.5 mg of Jurkat cell lysate.

生物信息
免疫原品种	GST-tagged recombinant protein corresponding to rat PI3 Kinase, p85.
宿主	Rabbit
品种反应性	RatHuman
Species Reactivity Note	Demonstrated to react with Human, and Rat. Predicted to react with Mouse, Bovine, and Monkey based on 100% sequence homology.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_037137
基因符号	Pik3r1
纯化方法	Affinity purified
UniProt编号	Q63787

理化信息

尺寸

材料信息

毒性学信息

GHS安全信息

安全信息

产品使用声明
质量保证	Evaluated by Western Blotting in Jurkat cell lysate. Western Blotting Analysis: A 1:600 dilution of this antibody detected PI3 Kinase, p85 in 10 µg of Jurkat cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	200 µL

运输信息

补充信息

规格

merck millipore,默克密理博,ABS234,Anti-PI3 Kinase Antibody, p85

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