merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE287,Anti-Topoisomerase II Antibody, clone SWT3D1

  • merck millipore,默克密理博,MABE287,Anti-Topoisomerase II Antibody, clone SWT3D1

    产品名称：Anti-Topoisomerase II Antibody, clone SWT3D1
    产品型号：MABE287
    Use Anti-Topoisomerase II Antibody, clone SWT3D1 (Mouse Monoclonal Antibody) validated in WB, IHC to detect Topoisomerase II also known as DNA topoisomerase 2-alpha.

    merck millipore,默克密理博,MABE287,Anti-Topoisomerase II Antibody, clone SWT3D1

  • 产品介绍
  • merck millipore,默克密理博,MABE287,Anti-Topoisomerase II Antibody, clone SWT3D1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE287
    描述 Anti-Topoisomerase II Antibody, clone SWT3D1
    Alternate Names
    • DNA topoisomerase II, alpha isozyme
    • DNA topoisomerase 2-alpha
    背景信息 Topoisomerase II is a nuclear enzyme whose primary function is to induce temporary double-strand breaks in DNA and to facilitate the passage of the duplex DNA segments through these breaks. Phosphorylation of topoisomerase II in a cell cycle regulated manner appears to be important for progression through the cell cycle. The enzyme exists as two discrete isozymes, topoisomerase IIα (~170 kDa) and topoisomerase IIβ (~180 kDa) which are under independent transcriptional regulation. Both isozymes have been identified in human and mouse cells but only the topoisomerase IIα form appears in yeast. The gene encoding topoisomerase IIα has been mapped to chromosome 17 and is in close proximity to the gene for erbB-2. Altered expression of topoisomerase II has been documented in many cancers including AML, CLL, small cell lung cancer, breast and ovarian cancer, and colon cancer. Based on this observation, topoisomerase II has been identified as the target of many widely used antineoplastic drugs as well as the target of rational drug design.« Collapse
    产品信息
    格式 Purified
    控制
    • HeLa nuclear extract
    演示 Purified mouse monoclonal IgG1κ cultured supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-Topoisomerase II Antibody, clone SWT3D1 (Mouse Monoclonal Antibody) validated in WB, IHC to detect Topoisomerase II also known as DNA topoisomerase 2-alpha.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Topoisomerase II in human tonsil tissue.
    生物信息
    免疫原品种 Recombinant protein corresponding to human Topoisomerase II.
    克隆 SWT3D1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    同种型 IgG1κ
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001058
    基因符号
    • TOP2
    • TOP2A
    纯化方法 Protein G purified
    UniProt编号
    • P11388
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa nuclear extract.

    Western Blot Analysis: A 1:1,000 dilution of this antibody detected Topoisomerase II on 10 µg of HeLa nuclear extract.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,MABE287,Anti-Topoisomerase II Antibody, clone SWT3D1

上一件merck millipore产品：merck millipore,默克密理博,14-786M,PI3 Kinase (p110α/p65α) Murine, 250 µg
下一件merck millipore产品：merck millipore,默克密理博,OS03B,Goat Anti-Rabbit IgG Biotin Conjugate


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